{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:48:13Z","timestamp":1792082893311,"version":"4.4.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100011856","name":"Mauritius Research Council","doi-asserted-by":"publisher","award":["MR\/P022596\/1"],"award-info":[{"award-number":["MR\/P022596\/1"]}],"id":[{"id":"10.13039\/501100011856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011856","name":"Mauritius Research Council","doi-asserted-by":"publisher","award":["MR\/N017846\/1"],"award-info":[{"award-number":["MR\/N017846\/1"]}],"id":[{"id":"10.13039\/501100011856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:p>\n            In\n            <jats:italic>Enterobacteriales<\/jats:italic>\n            , the AcrAB-TolC efflux pump exports substrates, including antimicrobials, from the cell. Overexpression of AcrAB-TolC can occur after exposure to fluoroquinolones, leading to multidrug resistance. The expression of AcrAB-TolC in\n            <jats:italic>Salmonella<\/jats:italic>\n            is primarily regulated by the transcriptional activator RamA. However, other transcriptional activators, such as MarA, SoxRS, and Rob, can influence AcrAB-TolC expression. This study determined whether the overproduction or absence of RamA influences the mutation rate or the phenotype of mutants selected in\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovar Typhimurium SL1344 after ciprofloxacin exposure.\n          <\/jats:p>","DOI":"10.1128\/aac.02460-19","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T09:48:16Z","timestamp":1579772896000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Overexpression of RamA, Which Regulates Production of the Multidrug Resistance Efflux Pump AcrAB-TolC, Increases Mutation Rate and Influences Drug Resistance Phenotype"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-2598","authenticated-orcid":false,"given":"Elizabeth M.","family":"Grimsey","sequence":"first","affiliation":[{"name":"Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Weston","sequence":"additional","affiliation":[{"name":"Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Ricci","sequence":"additional","affiliation":[{"name":"Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-473X","authenticated-orcid":false,"given":"Laura J. 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