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In these models, animals are infected with recombinant\n                    <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n                    carrying genes of interest under transcriptional control of the doxycycline-responsive TetR-\n                    <jats:italic>tetO<\/jats:italic>\n                    unit. To minimize fluctuations of plasma levels, doxycycline is usually administered in the diet. However, tissue penetration studies to identify the minimum doxycycline content in food achieving complete repression of TetR-controlled genes in tuberculosis (TB)-infected organs and lesions have not been conducted.\n                  <\/jats:p>","DOI":"10.1128\/aac.02479-19","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T07:30:48Z","timestamp":1581406248000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Tissue Distribution of Doxycycline in Animal Models of Tuberculosis"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-5920","authenticated-orcid":false,"given":"Martin","family":"Gengenbacher","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew 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