{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:00:26Z","timestamp":1792166426889,"version":"4.4.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            After a relatively short untreated interval, pneumonic plague has a mortality approaching 100%. We employed a murine model of aerosol challenge with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Yersinia pestis<\/jats:named-content>\n            to investigate the early course of pneumonic plague in the lung, blood, and spleen. We fit a mathematical model to all data simultaneously. The model fit to the data was acceptable. The number of organisms in the lung at baseline was estimated to be 135 (median) or 1,184 (mean) CFU\/g. The doubling time was estimated as 1.5 to 1.7 h. Between 1 and 12 h postexposure, counts declined, but they then increased by 24 h, a finding hypothesized to be due to innate immunity. The model predicted that innate immunity declined with a half-time of 3 to 3.8 h. The threshold for bacteremia was 6.4 \u00d7 10\n            <jats:sup>4<\/jats:sup>\n            to 1.52 \u00d7 10\n            <jats:sup>6<\/jats:sup>\n            CFU\/g. By 42 to 48 h, stationary phase was obtained. Lung bacterial burdens exceeded 10 log CFU\/g. Obviating early defenses allows for rapid amplification of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Y. pestis<\/jats:named-content>\n            in bacteremia, making the rapid course with high mortality understandable.\n          <\/jats:p>","DOI":"10.1128\/aac.02504-12","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T01:16:33Z","timestamp":1360718193000},"page":"2010-2015","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Natural History of Yersinia pestis Pneumonia in Aerosol-Challenged BALB\/c Mice"],"prefix":"10.1128","volume":"57","author":[{"given":"Henry S.","family":"Heine","sequence":"first","affiliation":[{"name":"Institute for Therapeutic Innovation, Department of Medicine, University of Florida, School of Medicine, Lake Nona, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Chuvala","sequence":"additional","affiliation":[{"name":"Institute for Therapeutic Innovation, Department of Medicine, University of Florida, School of Medicine, Lake Nona, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaldo","family":"Riggins","sequence":"additional","affiliation":[{"name":"Institute for Therapeutic Innovation, Department of Medicine, University of Florida, School of Medicine, Lake Nona, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Hurteau","sequence":"additional","affiliation":[{"name":"Institute for Therapeutic Innovation, Department of Medicine, University of Florida, School of Medicine, Lake Nona, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Cirz","sequence":"additional","affiliation":[{"name":"Achaogen, Inc., South San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cass","sequence":"additional","affiliation":[{"name":"Achaogen, Inc., South San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Louie","sequence":"additional","affiliation":[{"name":"Institute for Therapeutic Innovation, Department of Medicine, University of Florida, School of Medicine, Lake Nona, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Drusano","sequence":"additional","affiliation":[{"name":"Institute for Therapeutic Innovation, Department of Medicine, University of Florida, School of Medicine, Lake Nona, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0809.010536"},{"key":"e_1_3_2_3_2","volume-title":"A treatise on pneumonic plague.","author":"Wu L-T","year":"1926","unstructured":"WuL-T. 1926. A treatise on pneumonic plague. League of Nations Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.675"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/520547"},{"key":"e_1_3_2_6_2","volume-title":"Guide for the care and use of laboratory animals.","author":"National Research Council","year":"1996","unstructured":"National Research Council. 1996. Guide for the care and use of laboratory animals. National Academies Press, Washington, DC."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.109"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8502(73)90006-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2003.07.001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1947.150.1.70"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1109\/CBMS.2001.941750"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268811001245"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.59.030804.121320"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)74210-3"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.2731623.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134306"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02504-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02504-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:49:12Z","timestamp":1645451352000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02504-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1128\/AAC.02504-12"],"URL":"https:\/\/doi.org\/10.1128\/aac.02504-12","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"2012-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}