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The genetic relatedness of 88 isolates collected from multiple outbreaks and sporadic cases of nosocomial salmonellosis in various parts of Russia, Belarus, and Kazakhstan from 1996 to 2009 was established by multilocus tandem-repeat analysis (MLVA) and multilocus sequence typing (MLST). The isolates belong to sequence type 328 (ST328) and produce CTX-M-5 \u03b2-lactamase, whose gene is carried by highly related non-self-conjugative but mobilizable plasmids. Resistance to nalidixic acid and low-level resistance to ciprofloxacin is present in 37 (42%) of the isolates and in all cases is determined by various single point mutations in the<jats:italic>gyrA<\/jats:italic>gene quinolone resistance-determining region (QRDR). Isolates of the described clonal group exhibit a hypermutable phenotype that probably facilitates independent acquisition of quinolone resistance mutations.<\/jats:p>","DOI":"10.1128\/aac.02506-14","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T06:08:33Z","timestamp":1403590113000},"page":"5202-5210","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Long-Term Dissemination of CTX-M-5-Producing Hypermutable Salmonella enterica Serovar Typhimurium Sequence Type 328 Strains in Russia, Belarus, and Kazakhstan"],"prefix":"10.1128","volume":"58","author":[{"given":"Varvara K.","family":"Kozyreva","sequence":"first","affiliation":[{"name":"Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, Smolensk, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena N.","family":"Ilina","sequence":"additional","affiliation":[{"name":"Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja V.","family":"Malakhova","sequence":"additional","affiliation":[{"name":"Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Carattoli","sequence":"additional","affiliation":[{"name":"Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya S.","family":"Azizov","sequence":"additional","affiliation":[{"name":"Karaganda State Medical University, Karaganda, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry V.","family":"Tapalski","sequence":"additional","affiliation":[{"name":"Gomel State Medical University, Gomel, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman S.","family":"Kozlov","sequence":"additional","affiliation":[{"name":"Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, Smolensk, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail V.","family":"Edelstein","sequence":"additional","affiliation":[{"name":"Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, Smolensk, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0902.020185"},{"key":"e_1_3_2_3_2","volume-title":"About sanitary epidemiological situation in Russian Federation in 2010: national report","author":"Federal Center of Hygiene and Epidemiology of Federal Service on Customers' Rights Protection and Human Well-being Surveillance","year":"2011","unstructured":"Federal Center of Hygiene and Epidemiology of Federal Service on Customers' Rights Protection and Human Well-being Surveillance. 2011. 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