{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:04:59Z","timestamp":1761581099871},"reference-count":25,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both infections. Each of the constituent components of artemether-lumefantrine, the first-line regimen for malaria treatment in Nigeria, and nevirapine, a major component of highly active antiretroviral therapy, are drugs metabolized by the cytochrome P450 3A4 isoenzyme system, which is also known to be induced by nevirapine. We examined potential interactions between lumefantrine and nevirapine in 68 HIV-positive adults, all of whom were diagnosed with asymptomatic\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            infections by microscopy.\n            <jats:italic>Post hoc<\/jats:italic>\n            PCR analysis confirmed the presence of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. falciparum<\/jats:named-content>\n            in only a minority of participants. Day 7 capillary blood levels of lumefantrine were significantly higher in HIV-positive participants than in 99 HIV-negative controls (\n            <jats:italic>P<\/jats:italic>\n            = 0.0011). Associations between day 7 levels of lumefantrine and risk of persistent parasitemia could not be evaluated due to inadequate power. Further investigations of the impact of nevirapine on\n            <jats:italic>in vivo<\/jats:italic>\n            malaria treatment outcomes in HIV-infected patients are thus needed.\n          <\/jats:p>","DOI":"10.1128\/aac.02508-12","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T03:04:57Z","timestamp":1371524697000},"page":"4146-4150","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["HIV-Positive Nigerian Adults Harbor Significantly Higher Serum Lumefantrine Levels than HIV-Negative Individuals Seven Days after Treatment for Plasmodium falciparum Infection"],"prefix":"10.1128","volume":"57","author":[{"given":"Ifeyinwa","family":"Chijioke-Nwauche","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Management, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria"},{"name":"Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, LSHTM, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"van Wyk","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Faculty of Infectious and Tropical Diseases, LSHTM, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chijioke","family":"Nwauche","sequence":"additional","affiliation":[{"name":"Department of Haematology, Blood Transfusion and Immunology, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria"},{"name":"Centre for Malaria Research &amp; Phytomedicine, University of Port Harcourt, Rivers State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid B.","family":"Beshir","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, LSHTM, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harparkash","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Faculty of Infectious and Tropical Diseases, LSHTM, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin J.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, LSHTM, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000174445.40379.e0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1109.050337"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02727-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00830.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-S1-S4"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05265-11"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00060-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05136-11"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(98)90917-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.697-704.2000"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/313857"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01843.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.3.537"},{"key":"e_1_3_2_15_2","first-page":"48","article-title":"An assessment of high risk sexual behavior and HIV transmission-among migrant oil workers in the Niger Delta area of Nigeria","volume":"9","author":"Nwauche CA","year":"2006","unstructured":"NwaucheCAAkaniCI. 2006. An assessment of high risk sexual behavior and HIV transmission-among migrant oil workers in the Niger Delta area of Nigeria. Niger J. Clin. Pract. 9:48\u201351.","journal-title":"Niger J. Clin. Pract."},{"key":"e_1_3_2_16_2","volume-title":"National HIV sero-prevalence sentinel survey among pregnant women attending antenatal clinics in Nigeria","author":"Federal Ministry of Health Nigeria","year":"2008","unstructured":"Federal Ministry of Health Nigeria. 2008. Technical report (2008). National HIV sero-prevalence sentinel survey among pregnant women attending antenatal clinics in Nigeria. FMOH, Abuja, Nigeria."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.07.015"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-68"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00875-06"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-312"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0199-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks207"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.69.558"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/503051"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020092"},{"key":"e_1_3_2_26_2","first-page":"45","article-title":"Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school-children","volume":"3","author":"Dinko B","year":"2013","unstructured":"DinkoBOguikeMCLarbiJBBousemaJTSutherlandCJ. 2013. Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school-children. Int. J. Parasitol. DDR 3:45\u201350.","journal-title":"Int. J. Parasitol. 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