{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:35:37Z","timestamp":1791894937843,"version":"4.3.4"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"crossref","award":["2014-67015-22106"],"award-info":[{"award-number":["2014-67015-22106"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI 111341"],"award-info":[{"award-number":["R01 AI 111341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD 080670"],"award-info":[{"award-number":["R01 HD 080670"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU13\/03438"],"award-info":[{"award-number":["FPU13\/03438"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["P2018\/BAA-4370"],"award-info":[{"award-number":["P2018\/BAA-4370"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013325","name":"Swiss Re Foundation","doi-asserted-by":"publisher","award":["310030 165782"],"award-info":[{"award-number":["310030 165782"]}],"id":[{"id":"10.13039\/100013325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Previous studies on drug efficacy showed low protection against abortion and vertical transmission of<jats:named-content content-type=\"genus-species\">Toxoplasma gondii<\/jats:named-content>in pregnant sheep. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against several apicomplexan parasites<jats:italic>in vitro<\/jats:italic>and in laboratory animal models.<\/jats:p>","DOI":"10.1128\/aac.02527-18","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T14:43:05Z","timestamp":1556808185000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy"],"prefix":"10.1128","volume":"63","author":[{"given":"Roberto","family":"S\u00e1nchez-S\u00e1nchez","sequence":"first","affiliation":[{"name":"SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ferre","sequence":"additional","affiliation":[{"name":"SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Re","sequence":"additional","affiliation":[{"name":"SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"},{"name":"Department of Animal Medicine and Surgery, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Ramos","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda Animal. Facultad de Veterinaria C\/Miguel Servet 177, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Regidor-Cerrillo","sequence":"additional","affiliation":[{"name":"SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pizarro D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gonz\u00e1lez-Huecas","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Tabanera","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Benavides","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-Universidad de Le\u00f3n), Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hemphill","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Vetsuisse Faculty, University of Bern, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Hulverson","sequence":"additional","affiliation":[{"name":"Center for Emerging and Reemerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn K.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Center for Emerging and Reemerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Emerging and Reemerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Whitman","sequence":"additional","affiliation":[{"name":"Center for Emerging and Reemerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayode K.","family":"Ojo","sequence":"additional","affiliation":[{"name":"Center for Emerging and Reemerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley C.","family":"Van Voorhis","sequence":"additional","affiliation":[{"name":"Center for Emerging and Reemerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-6783","authenticated-orcid":false,"given":"Luis Miguel","family":"Ortega-Mora","sequence":"additional","affiliation":[{"name":"SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Toxoplasmosis of animals and humans","author":"Dubey J","year":"2010","unstructured":"Dubey J. 2010. Toxoplasmosis of animals and humans. CRC Press, Boca Raton, FL."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991636"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2007.07.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)31120-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.142.17.445"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-45-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-016-0327-z"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.02.026"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666181002113617"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.129.5.89"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.133.13.310"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.120.26.618"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(88)90021-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.132.16.409"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.138.18.434"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(96)80059-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.09.044"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09022"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ml100096t"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1818"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017001901"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011045200"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.299"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2017.01.001"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01236-15"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb400115y"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01823-13"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx134"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.01.004"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407704-1.00007-5"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw488"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00760"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit522"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2006.00831.x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00319"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00436"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-06-0042"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006001855"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.02.003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.4049\/jimmunol.141.10.3600","article-title":"Induction of antigen-specific parasiticidal cytotoxic T cell splenocytes by a major membrane protein (P30) of Toxoplasma gondii","volume":"141","author":"Khan IA","year":"1988","unstructured":"Khan IA, Smith KA, Kasper LH. 1988. Induction of antigen-specific parasiticidal cytotoxic T cell splenocytes by a major membrane protein (P30) of Toxoplasma gondii. J Immunol 141:3600\u20133605.","journal-title":"J Immunol"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0539"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200112144"},{"key":"e_1_3_3_44_2","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.4049\/jimmunol.150.9.3951","article-title":"Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection","volume":"150","author":"Mineo JR","year":"1993","unstructured":"Mineo JR, McLeod R, Mack D, Smith J, Khan IA, Ely KH, Kasper LH. 1993. Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection. J Immunol 150:3951\u20133964.","journal-title":"J Immunol"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.04.035"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-169052-1\/50003-X"},{"key":"e_1_3_3_47_2","volume-title":"La exploraci\u00f3n cl\u00ednica del ganado ovino y su entorno","author":"Ramos-Ant\u00f3n JJ","year":"2007","unstructured":"Ramos-Ant\u00f3n JJ, Ferrer-Mayayo LM. 2007. La exploraci\u00f3n cl\u00ednica del ganado ovino y su entorno. Servet, Zaragoza, Spain."},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.08.002"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(02)00091-2"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2003009"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02527-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02527-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:18:22Z","timestamp":1694848702000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02527-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1128\/AAC.02527-18"],"URL":"https:\/\/doi.org\/10.1128\/aac.02527-18","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2018-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02527-18"}}