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To discover new antiviral agents, we performed a compound screen in cell culture-based infection models and identified two carbocyclic adenosine analogues, 6\u2032-\u03b2-fluoro-homoaristeromycin (FHA) and 6\u2032-fluoro-homoneplanocin A (FHNA), that displayed potent activity against CHIKV and Semliki Forest virus (SFV) with 50% effective concentrations in the nanomolar range at nontoxic concentrations.<\/jats:p>","DOI":"10.1128\/aac.02532-19","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T09:30:12Z","timestamp":1579685412000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["6\u2032-\u03b2-Fluoro-Homoaristeromycin and 6\u2032-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 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