{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:27:47Z","timestamp":1779222467201,"version":"3.51.4"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Nitazoxanide (NTZ) has bactericidal activity against the\n            <jats:italic>H37Rv<\/jats:italic>\n            laboratory strain of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium tuberculosis<\/jats:named-content>\n            with a MIC of 16 \u03bcg\/ml. However, its efficacy against clinical isolates of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. tuberculosis<\/jats:named-content>\n            has not been determined. We found that NTZ's MIC against 50 clinical isolates ranged from 12 to 28 \u03bcg\/ml with a median of 16 \u03bcg\/ml and was unaffected by resistance to first- or second-line antituberculosis drugs or a diversity of spoligotypes.\n          <\/jats:p>","DOI":"10.1128\/aac.02542-12","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T07:06:07Z","timestamp":1363676767000},"page":"2834-2837","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Efficacy of Nitazoxanide against Clinical Isolates of Mycobacterium tuberculosis"],"prefix":"10.1128","volume":"57","author":[{"given":"Kristina","family":"Shigyo","sequence":"first","affiliation":[{"name":"Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA"},{"name":"Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Ocheretina","sequence":"additional","affiliation":[{"name":"Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves Mary","family":"Merveille","sequence":"additional","affiliation":[{"name":"GHESKIO Centres, Port-au-Prince, Haiti"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean William","family":"Pape","sequence":"additional","affiliation":[{"name":"Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA"},{"name":"GHESKIO Centres, Port-au-Prince, Haiti"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl F.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2012.02.009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3126\/kumj.v8i1.3234"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60734-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068273"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70105-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/505877"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60085-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2427"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(08)70034-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09657"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01066.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/321008"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.2.6.583"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm200153p"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.1.103"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.8.1959"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.020"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.08.005"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181bf9b15"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03781.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm201264t"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.056"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9010719"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214188109"},{"key":"e_1_3_2_26_2","volume-title":"NCCLS document M24-A","author":"National Committee for Clinical Laboratory Standards (NCCLS)","year":"2003","unstructured":"National Committee for Clinical Laboratory Standards (NCCLS). 2003. 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