{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:51:55Z","timestamp":1790823115790,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"MINECO and FEDER","award":["CSD2010-00065-2010"],"award-info":[{"award-number":["CSD2010-00065-2010"]}]},{"name":"MINECO and FEDER","award":["CTQ2013-48917"],"award-info":[{"award-number":["CTQ2013-48917"]}]},{"name":"FPU GRANT","award":["FPU14\/01537"],"award-info":[{"award-number":["FPU14\/01537"]}]},{"name":"ISTUN","award":["API-2011\/02"],"award-info":[{"award-number":["API-2011\/02"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro<\/jats:italic>\n            leishmanicidal activities of a series of 48 recently synthesized selenium derivatives against\n            <jats:named-content content-type=\"genus-species\">Leishmania infantum<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Leishmania braziliensis<\/jats:named-content>\n            parasites were tested using promastigotes and intracellular amastigote forms. The cytotoxicity of the tested compounds for J774.2 macrophage cells was also measured in order to establish their selectivity. Six of the tested compounds (compounds 8, 10, 11, 15, 45, and 48) showed selectivity indexes higher than those of the reference drug, meglumine antimonate (Glucantime), for both\n            <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n            species; in the case of\n            <jats:named-content content-type=\"genus-species\">L. braziliensis<\/jats:named-content>\n            , compound 20 was also remarkably selective. Moreover, data on infection rates and amastigote numbers per macrophage showed that compounds 8, 10, 11, 15, 45, and 48 were the most active against both\n            <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n            species studied. The observed changes in the excretion product profile of parasites treated with these six compounds were also consistent with substantial cytoplasmic alterations. On the other hand, the most active compounds were potent inhibitors of Fe superoxide dismutase (Fe-SOD) in the two parasite species considered, whereas their impact on human CuZn-SOD was low. The high activity, low toxicity, stability, low cost of the starting materials, and straightforward synthesis make these compounds appropriate molecules for the development of affordable antileishmanicidal agents.\n          <\/jats:p>","DOI":"10.1128\/aac.02546-16","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:35:18Z","timestamp":1490056518000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Library of Seleno-Compounds as Novel Agents against Leishmania Species"],"prefix":"10.1128","volume":"61","author":[{"given":"\u00c1lvaro","family":"Mart\u00edn-Montes","sequence":"first","affiliation":[{"name":"Universidad de Granada, Departamento de Parasitolog\u00eda, Facultad de Ciencias, Severo Ochoa s\/n, Granada, Spain, and Instituto de Investigaci\u00f3n Biosanitaria (ibs. Granada), Hospitales Universitarios de Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Plano","sequence":"additional","affiliation":[{"name":"University of Navarra, Faculty of Pharmacy and Nutrition, Departament of Organic and Pharmaceutical Chemistry, Campus Universitario, Pamplona, Spain"},{"name":"IdiSNA, Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Mart\u00edn-Escolano","sequence":"additional","affiliation":[{"name":"Universidad de Granada, Departamento de Parasitolog\u00eda, Facultad de Ciencias, Severo Ochoa s\/n, Granada, Spain, and Instituto de Investigaci\u00f3n Biosanitaria (ibs. 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