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For many years, chemotherapeutical treatment against alveolar echinococcosis has relied on the benzimidazoles albendazole and mebendazole, which require long treatment durations and exhibit parasitostatic rather than parasiticidal efficacy. Although benzimidazoles have been and still are beneficial for the patients, there is clearly a demand for alternative and more efficient treatment options. Aromatic dications, more precisely a small panel of di-<jats:italic>N<\/jats:italic>-aryl-diguanidino compounds, were screened for efficacy against<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. multilocularis<\/jats:named-content>metacestodes<jats:italic>in vitro<\/jats:italic>. Only those with a thiophene core group were active against metacestodes, while furans were not. The most active compound, DB1127, was further investigated in terms of<jats:italic>in vivo<\/jats:italic>efficacy in mice experimentally infected with<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. multilocularis<\/jats:named-content>metacestodes. This diguanidino compound was effective against AE when administered intraperitoneally but not when applied orally. Thus, thiophene-diguanidino derivatives with improved bioavailability when administered orally could lead to treatment options against AE.<\/jats:p>","DOI":"10.1128\/aac.02569-12","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T04:58:59Z","timestamp":1369803539000},"page":"3829-3835","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["<i>In Vitro<\/i>and<i>In Vivo<\/i>Activities of Dicationic Diguanidino Compounds against Echinococcus multilocularis Metacestodes"],"prefix":"10.1128","volume":"57","author":[{"given":"Tatiana","family":"K\u00fcster","sequence":"first","affiliation":[{"name":"Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Kriegel","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Boykin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Georgia State University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad E.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics, Georgia Regents University, Augusta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hemphill","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.07.024"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06355-11"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01701.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2011.49.4.413"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001524"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001379"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.7883\/yoken.63.80","article-title":"Echinococcus multilocularis detected in slaughtered pigs in Aomori, the northernmost prefecture of mainland Japan","volume":"63","author":"Kimura M","year":"2010","unstructured":"KimuraM ToukairinA TatezakiH TanakaS HaradaK AraiyamaJ YamasakiH SugiyamaH MorishimaY KawanakaM. 2010. 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