{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:28:27Z","timestamp":1790742507826,"version":"4.1.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.<\/jats:p>","DOI":"10.1128\/aac.02597-15","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T04:13:39Z","timestamp":1456200819000},"page":"3148-3151","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections"],"prefix":"10.1128","volume":"60","author":[{"given":"Sylvain","family":"Goutelle","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon, Groupement Hospitalier de G\u00e9riatrie, Service Pharmaceutique, Lyon, France"},{"name":"ISPB, Facult\u00e9 de Pharmacie de Lyon, Universit\u00e9 Lyon 1, Lyon, France"},{"name":"UMR CNRS 5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, Universit\u00e9 Lyon 1, Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Roux","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Gagnieu","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, Laboratoire de Biochimie et Biologie Mol\u00e9culaire, UF de Pharmacologie Sp\u00e9cialis\u00e9e, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Valour","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Lustig","sequence":"additional","affiliation":[{"name":"Claude Bernard Lyon 1 University, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Ader","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France"},{"name":"Claude Bernard Lyon 1 University, Lyon, France"},{"name":"International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Laurent","sequence":"additional","affiliation":[{"name":"ISPB, Facult\u00e9 de Pharmacie de Lyon, Universit\u00e9 Lyon 1, Lyon, France"},{"name":"Claude Bernard Lyon 1 University, Lyon, France"},{"name":"International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Chidiac","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France"},{"name":"Claude Bernard Lyon 1 University, Lyon, France"},{"name":"International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Ferry","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France"},{"name":"Claude Bernard Lyon 1 University, Lyon, France"},{"name":"International Centre for Research in Infectiology, CIRI, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis803"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.2799-2807.2004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02000-12"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.06.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt342"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.077180"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.14"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03261932"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109868"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01113502"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.63-68.2004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/652767"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq109"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02597-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02597-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:50:46Z","timestamp":1645476646000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02597-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1128\/AAC.02597-15"],"URL":"https:\/\/doi.org\/10.1128\/aac.02597-15","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"2015-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}