{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:56:05Z","timestamp":1791424565323,"version":"4.3.3"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Few oral antibiotics exist for the empirical treatment of extended-spectrum \u03b2-lactamase (ESBL) urinary tract infections (UTI). In this study, we sought to determine the activity of fosfomycin against ESBL-producing uropathogens from patients at 3 Veterans Affairs (VA) facilities between 2010 and 2013. Among the ESBL uropathogens, 19.9% were fosfomycin resistant.\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella<\/jats:named-content>\n                    species were more likely than\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n                    to be resistant (46% versus 4%;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Fosfomycin remains active against a majority of the ESBL uropathogens, although resistance among\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella<\/jats:named-content>\n                    spp. was higher than that in previous reports.\n                  <\/jats:p>","DOI":"10.1128\/aac.02614-15","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T21:43:29Z","timestamp":1448315009000},"page":"1134-1136","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Activity of Fosfomycin against Extended-Spectrum-\u03b2-Lactamase-Producing Uropathogens in Patients in the Community and Hospitalized Patients"],"prefix":"10.1128","volume":"60","author":[{"given":"Katherine","family":"Linsenmeyer","sequence":"first","affiliation":[{"name":"VA Boston Healthcare System, West Roxbury, Massachusetts, USA"},{"name":"Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Strymish","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System, West Roxbury, Massachusetts, USA"},{"name":"Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Weir","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System, West Roxbury, Massachusetts, USA"},{"name":"Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Berg","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System, West Roxbury, Massachusetts, USA"},{"name":"Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Brecher","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System, West Roxbury, Massachusetts, USA"},{"name":"Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Gupta","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System, West Roxbury, Massachusetts, USA"},{"name":"Boston University School of Medicine, Boston, Massachusetts, USA"},{"name":"National Center for Occupational Health and Infection Control, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2010.538856"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12321"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"ITC3","DOI":"10.7326\/0003-4819-156-5-201203060-01003","article-title":"In the clinic. Urinary tract infection","volume":"156","author":"Gupta K","year":"2012","unstructured":"Gupta K, Trautner B. 2012. In the clinic. Urinary tract infection. Ann Intern Med 156:ITC3-1\u2013ITC3-15.","journal-title":"Ann Intern Med"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1031-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2013.56"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00402-12"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-011-0132-6"},{"key":"e_1_3_2_9_2","first-page":"43","article-title":"Increasing prevalence of fosfomycin resistance in extended-spectrum-beta-lactamase-producing Escherichia coli urinary isolates (2005\u20132009\u20132011)","volume":"26","author":"Rodriguez-Avial C","year":"2013","unstructured":"Rodriguez-Avial C, Rodriguez-Avial I, Hernandez E, Picazo JJ. 2013. Increasing prevalence of fosfomycin resistance in extended-spectrum-beta-lactamase-producing Escherichia coli urinary isolates (2005\u20132009\u20132011). Rev Esp Quimioter 26:43\u201346. (In Spanish.)","journal-title":"Rev Esp Quimioter"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.10.005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq108"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01402-10"},{"key":"e_1_3_2_13_2","volume-title":"Performance standards for antimicrobial susceptibility testing; 19th informational supplement","author":"Clinical and Laboratory Standards Institute","unstructured":"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 19th informational supplement. CLSI document M100-19. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_14_2","volume-title":"Performance standards for antimicrobial susceptibility testing; 24th informational supplement","author":"Clinical and Laboratory Standards Institute","unstructured":"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 24th informational supplement. CLSI document M100-S24. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.368-370.2006"},{"key":"e_1_3_2_16_2","first-page":"57","article-title":"The prevalence and susceptibility patterns of ESBL-producing Klebsiella pneumonia and Escherichia coli in Chonburi Hospital","volume":"23","author":"Waiwarawooth J","year":"2006","unstructured":"Waiwarawooth J, Jutiworakul K, Joraka W. 2006. The prevalence and susceptibility patterns of ESBL-producing Klebsiella pneumonia and Escherichia coli in Chonburi Hospital. J Infect Dis Antimicrob Agents 23:57\u201365.","journal-title":"J Infect Dis Antimicrob Agents"},{"key":"e_1_3_2_17_2","first-page":"11","article-title":"Current efficacy of antibiotics against Klebsiella isolates from urine samples\u2013a multi-centric experience in Karachi","volume":"26","author":"Abdullah FEMA","year":"2013","unstructured":"Abdullah FEMA, Ishrad M, Rauf H, Afzal N, Rasheed A. 2013. Current efficacy of antibiotics against Klebsiella isolates from urine samples\u2013a multi-centric experience in Karachi. Pak J Pharm Sci 26:11\u201315.","journal-title":"Pak J Pharm Sci"},{"key":"e_1_3_2_18_2","first-page":"121","article-title":"Activity of fosfomycin against extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae and Escherichia coli in Maharaj Nakorn Chiang Mai Hospital","volume":"22","author":"Tharavichitkul P","year":"2005","unstructured":"Tharavichitkul P, Khantawa B, Bousoung V, Boonchoo M. 2005. Activity of fosfomycin against extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae and Escherichia coli in Maharaj Nakorn Chiang Mai Hospital. J Infect Dis Antimicrob Agents 22:121\u2013126.","journal-title":"J Infect Dis Antimicrob Agents"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70041-0"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02614-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02614-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:32:08Z","timestamp":1645457528000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02614-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1128\/AAC.02614-15"],"URL":"https:\/\/doi.org\/10.1128\/aac.02614-15","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"2015-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}