{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:18:41Z","timestamp":1790381921340,"version":"4.1.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,4]]},"abstract":"ABSTRACT<\/jats:title>Although epidemiological cutoff values (ECVs) have been established forCandida<\/jats:named-content>spp. and the triazoles, they are based on MIC data from a single laboratory. We have established ECVs for eightCandida<\/jats:named-content>species and fluconazole, posaconazole, and voriconazole based on wild-type (WT) MIC distributions for isolates ofC. albicans<\/jats:named-content>(n<\/jats:italic>= 11,241 isolates),C. glabrata<\/jats:named-content>(7,538),C. parapsilosis<\/jats:named-content>(6,023),C. tropicalis<\/jats:named-content>(3,748),C. krusei<\/jats:named-content>(1,073),C. lusitaniae<\/jats:named-content>(574),C. guilliermondii<\/jats:named-content>(373), andC. dubliniensis<\/jats:named-content>(162). The 24-h CLSI broth microdilution MICs were collated from multiple laboratories (in Canada, Brazil, Europe, Mexico, Peru, and the United States). The ECVs for distributions originating from \u22656 laboratories, which included \u226595% of the modeled WT population, for fluconazole, posaconazole, and voriconazole were, respectively, 0.5, 0.06 and 0.03 \u03bcg\/ml forC. albicans<\/jats:named-content>, 0.5, 0.25, and 0.03 \u03bcg\/ml forC. dubliniensis<\/jats:named-content>, 8, 1, and 0.25 \u03bcg\/ml forC. glabrata<\/jats:named-content>, 8, 0.5, and 0.12 \u03bcg\/ml forC. guilliermondii<\/jats:named-content>, 32, 0.5, and 0.25 \u03bcg\/ml forC. krusei<\/jats:named-content>, 1, 0.06, and 0.06 \u03bcg\/ml forC. lusitaniae<\/jats:named-content>, 1, 0.25, and 0.03 \u03bcg\/ml forC. parapsilosis<\/jats:named-content>, and 1, 0.12, and 0.06 \u03bcg\/ml forC. tropicalis<\/jats:named-content>. The low number of MICs (<100) for other less prevalent species (C. famata<\/jats:named-content>,C. kefyr<\/jats:named-content>,C. orthopsilosis<\/jats:named-content>,C. rugosa<\/jats:named-content>) precluded ECV definition, but their MIC distributions are documented. Evaluation of our ECVs for some species\/agent combinations using published individual MICs for 136 isolates (harboring mutations in or upregulation ofERG11<\/jats:italic>,MDR1<\/jats:italic>,CDR1<\/jats:italic>, orCDR2<\/jats:italic>) and 64 WT isolates indicated that our ECVs may be useful in distinguishing WT from non-WT isolates.<\/jats:p>","DOI":"10.1128\/aac.02615-13","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T05:33:01Z","timestamp":1389677581000},"page":"2006-2012","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":100,"title":["Multilaboratory Study of Epidemiological Cutoff Values for Detection of Resistance in Eight Candida Species to Fluconazole, Posaconazole, and Voriconazole"],"prefix":"10.1128","volume":"58","author":[{"given":"A.","family":"Espinel-Ingroff","sequence":"first","affiliation":[{"name":"VCU Medical Center, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Universidad Auton\u00f3ma de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"The Innsbruck Medical University, Division of Hygiene and Medical Microbiology, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Martin-Mazuelos","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Valme, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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