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Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring\n            <jats:italic>qnr<\/jats:italic>\n            determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.02615-16","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T02:21:00Z","timestamp":1484706060000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Plasmidic\n            <i>qnr<\/i>\n            Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological 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