{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:08:39Z","timestamp":1790712519161,"version":"4.1.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Large-scale testing of\n            <jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>\n            isolates has not been performed, and the frequency of clinical isolates with elevated amphotericin B or triazole MICs has not been evaluated.\n            <jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>\n            isolates (\n            <jats:italic>n<\/jats:italic>\n            = 581) underwent antifungal susceptibility testing. Elevated MIC values were observed for fluconazole (\u226516 \u03bcg\/ml, 37.3% of isolates; \u226532 \u03bcg\/ml, 7.9% of isolates), itraconazole (\u22652 \u03bcg\/ml, 1.0% of isolates), posaconazole (\u22651 \u03bcg\/ml, 1.0% of isolates), and voriconazole (\u22652 \u03bcg\/ml, 1.2% of isolates). However, mold-active triazoles exhibited low MICs for the majority of isolates tested. Additional correlation with patient outcomes to determine the relevance of elevated MICs in\n            <jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>\n            isolates is needed.\n          <\/jats:p>","DOI":"10.1128\/aac.02634-16","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T02:21:00Z","timestamp":1484706060000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["Large-Scale Evaluation of\n            <i>In Vitro<\/i>\n            Amphotericin B, Triazole, and Echinocandin Activity against Coccidioides Species from U.S. Institutions"],"prefix":"10.1128","volume":"61","author":[{"suffix":"III","given":"George R.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of California-Davis Medical Center, Sacramento, California, USA"},{"name":"Department of Medical Microbiology and Immunology, University of California-Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-4517","authenticated-orcid":false,"given":"Bridget M.","family":"Barker","sequence":"additional","affiliation":[{"name":"Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw360"},{"key":"e_1_3_2_3_2","volume-title":"ASM Microbe","author":"Thompson GR","year":"2016","unstructured":"Thompson GRIIIBarkerBMWiederholdNP. 2016. ASM Microbe,16 to 20 June 2016,Boston, MA,abstr. 300."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(97)00104-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-007-9018-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-014-9816-7"},{"key":"e_1_3_2_7_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard\u20142nd ed","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard\u20142nd ed. CLSI document M38A2. 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