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GRL-001-15 and GRL-003-15 have\n            <jats:italic>meta<\/jats:italic>\n            -monofluorophenyl and\n            <jats:italic>para<\/jats:italic>\n            -monofluorophenyl at the P1 site, respectively, exert highly potent activity against wild-type HIV-1 with 50% effective concentrations (EC\n            <jats:sub>50<\/jats:sub>\n            s) of 57 and 50 pM, respectively, and have favorable cytotoxicity profiles with 50% cytotoxic concentrations (CC\n            <jats:sub>50<\/jats:sub>\n            s) of 38 and 11\u2009\u03bcM, respectively.\n          <\/jats:p>","DOI":"10.1128\/aac.02635-18","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T10:36:06Z","timestamp":1554719766000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants"],"prefix":"10.1128","volume":"63","author":[{"given":"Shin-ichiro","family":"Hattori","sequence":"first","affiliation":[{"name":"Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haydar","family":"Bulut","sequence":"additional","affiliation":[{"name":"Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalapala Venkateswara","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, West Lafayette, Indiana, USA"},{"name":"Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanth R.","family":"Nyalapatla","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, West Lafayette, Indiana, USA"},{"name":"Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Protein Crystal Analysis Division, Japan Synchrotron Radiation Research Institute, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"},{"name":"Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, West Lafayette, Indiana, USA"},{"name":"Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Mitsuya","sequence":"additional","affiliation":[{"name":"Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"},{"name":"Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"},{"name":"Department of Clinical Sciences, Kumamoto University Hospital, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30086-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001014"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081355"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12421"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600693"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105243"},{"key":"e_1_3_3_8_2","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). 2018. 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