{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:21:03Z","timestamp":1781716863461,"version":"3.54.5"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31272455"],"award-info":[{"award-number":["31272455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572411"],"award-info":[{"award-number":["31572411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR16C170001"],"award-info":[{"award-number":["LR16C170001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Hepcidin, an antimicrobial peptide, was discovered to integrate diverse signals from iron status and an infection threat and orchestrate a series of host-protective responses. Several studies have investigated the antimicrobial role of hepcidin, but the results have been controversial. Here, we aimed to examine the role of hepcidin in bacterial adherence and invasion\n            <jats:italic>in vitro<\/jats:italic>\n            . We found that porcine hepcidin could decrease the amount of the extracellular pathogen enterotoxigenic\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            (ETEC) K88 that adhered to cells because it caused the aggregation of the bacteria. However, addition of hepcidin to macrophages infected with the intracellular pathogen\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovar Typhimurium enhanced the intracellular growth of the pathogen through the degradation of ferroportin, an iron export protein, and then the sequestration of intracellular iron. Intracellular iron was unavailable by use of the iron chelator deferiprone (DFO), which reduced intracellular bacterial growth. These results demonstrate that hepcidin exhibits different functions in extracellular and intracellular bacterial infections, which suggests that different defense strategies should be taken to prevent bacterial infection.\n          <\/jats:p>","DOI":"10.1128\/aac.02638-16","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:35:13Z","timestamp":1501547713000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Synthetic Porcine Hepcidin Exhibits Different Roles in Escherichia coli and Salmonella Infections"],"prefix":"10.1128","volume":"61","author":[{"given":"Dan","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture, and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Shun","family":"Gan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture, and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture, and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Tao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture, and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Analysis Center of Agrobiology and Environmental Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture, and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Hua","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture, and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.04.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540558"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5446"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02925-14"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003901"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-126854"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0672"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008922200"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224577"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-258467"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004998"},{"key":"e_1_3_2_15_2","first-page":"183","article-title":"Hepcidin\u2014a peptide hormone at the interface of innate immunity and iron metabolism","volume":"306","author":"Ganz T","year":"2006","unstructured":"Ganz T . 2006. Hepcidin\u2014a peptide hormone at the interface of innate immunity and iron metabolism. 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