{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:59:26Z","timestamp":1792159166081,"version":"4.4.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Today's and Tomorrow's Children's Fund"},{"name":"UCLA Department of Pediatrics Nanopediatric Program"},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["AI107383"],"award-info":[{"award-number":["AI107383"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Antiviral drugs do not currently exist for the treatment of enterovirus infections, which are often severe and potentially life-threatening. We conducted high-throughput molecular screening and identified a structurally diverse set of compounds that inhibit the replication of coxsackievirus B3, a commonly encountered enterovirus. These compounds did not interfere with the function of the viral internal ribosome entry site or with the activity of the viral proteases, but they did drastically reduce the synthesis of viral RNA and viral proteins in infected cells. Sequence analysis of compound-resistant mutants suggests that the viral 2C protein is targeted by most of these compounds. These compounds demonstrated antiviral activity against a panel of the most commonly encountered enteroviruses and thus represent potential leads for the development of broad-spectrum anti-enteroviral drugs.<\/jats:p>","DOI":"10.1128\/aac.02646-15","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T03:23:15Z","timestamp":1451359395000},"page":"1615-1626","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses"],"prefix":"10.1128","volume":"60","author":[{"given":"Jun","family":"Zuo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Kye","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Damoiseaux","sequence":"additional","affiliation":[{"name":"California Nanosystems Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"},{"name":"Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Krogstad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"},{"name":"Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"2051","volume-title":"Textbook of pediatric infectious diseases","author":"Cherry JD","year":"2013","unstructured":"Cherry JD, Krogstad P. 2013. Enteroviruses and parechoviruses, p 2051\u20132109. In Feigin RD, Cherry JD, Demmler GJ, Kaplan S (ed), Textbook of pediatric infectious diseases, 7th ed. Elsevier, Philadelphia, PA.","edition":"7"},{"key":"e_1_3_3_3_2","first-page":"1059","article-title":"Progress toward poliomyelitis eradication\u2014Nigeria, January 2013-September 2014","volume":"63","author":"Etsano A","year":"2014","unstructured":"Etsano A, Gunnala R, Shuaib F, Damisa E, Mkanda P, Banda R, Korir C, Enemaku O, Corkum M, Usman S, Davis LB, Nganda G, Burns CC, Mahoney F, Vertefeuille JF, Centers for Disease Control and Prevention. 2014. Progress toward poliomyelitis eradication\u2014Nigeria, January 2013-September 2014. MMWR Morb Mortal Wkly Rep 63:1059\u20131063.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/318454"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2002.tb00601.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/605089"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/605090"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79925-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24410"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4188"},{"key":"e_1_3_3_11_2","first-page":"901","article-title":"Acute neurologic illness of unknown etiology in children\u2014Colorado, August-September 2014","volume":"63","author":"Pastula DM","year":"2014","unstructured":"Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L, Centers for Disease Control and Prevention. 2014. Acute neurologic illness of unknown etiology in children\u2014Colorado, August-September 2014. MMWR Morb Mortal Wkly Rep 63:901\u2013902.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_12_2","first-page":"798","article-title":"Severe respiratory illness associated with enterovirus D68\u2014Missouri and Illinois, 2014","volume":"63","author":"Midgley CM","year":"2014","unstructured":"Midgley CM, Jackson MA, Selvarangan R, Turabelidze G, Obringer E, Johnson D, Giles BL, Patel A, Echols F, Oberste MS, Nix WA, Watson JT, Gerber SI. 2014. Severe respiratory illness associated with enterovirus D68\u2014Missouri and Illinois, 2014. MMWR Morb Mortal Wkly Rep 63:798\u2013799.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4625"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1284"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/379830"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20125"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.04.002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.10.008"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.09.020"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00983-12"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4430-4440.2002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.11.7811-7818.1996"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.035"},{"key":"e_1_3_3_24_2","first-page":"1577","article-title":"Nonpolio enterovirus and human parechovirus surveillance\u2014United States, 2006-2008","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","unstructured":"Centers for Disease Control and Prevention. 2010. Nonpolio enterovirus and human parechovirus surveillance\u2014United States, 2006-2008. MMWR Morb Mortal Wkly Rep 59:1577\u20131580.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_25_2","first-page":"1","article-title":"Enterovirus surveillance\u2013United States, 1970-2005","volume":"55","author":"Khetsuriani N","year":"2006","unstructured":"Khetsuriani N, Lamonte-Fowlkes A, Oberst S, Pallansch MA, Centers for Disease Control and Prevention. 2006. Enterovirus surveillance\u2013United States, 1970-2005. MMWR Surveill Summ 55:1\u201320.","journal-title":"MMWR Surveill Summ"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.5.2377-2387.2001"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a118408"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp502"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.6992"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10138"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31816b5d2a"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00574-14"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/108705719900400206"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8482-8489.1997"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6434a3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02084-12"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.062497-0"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.57.2.638-646.1986"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.16.8973-8984.2003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.2.855-867.2004"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02646-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02646-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:40:34Z","timestamp":1645476034000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02646-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1128\/AAC.02646-15"],"URL":"https:\/\/doi.org\/10.1128\/aac.02646-15","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"2015-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}