{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:38:13Z","timestamp":1778744293334,"version":"3.51.4"},"reference-count":89,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008266","name":"K\u00f8bmand I Odense Johan og Hanne Weimann F\u00f8dt Seedorffs Legat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Ministry of Science, Innovation and Higher Education | Danish Agency for Science and Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Ministry of Science, Innovation and Higher Education | Danish Agency for Science and Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Ministry of Science, Innovation and Higher Education | Danish Agency for Science and Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,8,17]]},"abstract":"<jats:p>Antivirals targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could improve treatment of COVID-19. We evaluated the efficacy of clinically relevant hepatitis C virus (HCV) NS3 protease inhibitors (PIs) against SARS-CoV-2 and their interactions with remdesivir, the only direct-acting antiviral approved for COVID-19 treatment.<\/jats:p>","DOI":"10.1128\/aac.02680-20","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T18:38:48Z","timestamp":1623609528000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2\n                    <i>In Vitro<\/i>"],"prefix":"10.1128","volume":"65","author":[{"given":"Karen A.","family":"Gammeltoft","sequence":"first","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos R.","family":"Duarte Hernandez","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-430X","authenticated-orcid":true,"given":"Andrea","family":"Galli","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Offersgaard","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Costa","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long V.","family":"Pham","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik","family":"Fahn\u00f8e","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Feng","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-4067","authenticated-orcid":true,"given":"Troels K. H.","family":"Scheel","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-1814","authenticated-orcid":true,"given":"Santseharay","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-4806","authenticated-orcid":true,"given":"Jens","family":"Bukh","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-0256","authenticated-orcid":true,"given":"Judith M.","family":"Gottwein","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark"},{"name":"Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.5619"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25748"},{"key":"e_1_3_3_8_2","unstructured":"World Health Organization. 2020. WHO coronavirus disease (COVID-19). https:\/\/covid19.who.int\/."},{"key":"e_1_3_3_9_2","unstructured":"Johns Hopkins University. 2020. COVID-19 dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). https:\/\/coronavirus.jhu.edu\/map.html."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2007764"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.21475"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3248"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3046"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01140"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb3405"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2223-y"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0178-y"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2601-5"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.12.015"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25173920"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21060-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26744"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy401"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81351-3"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.4.2534-2539.1995"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01451.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.003"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8976-8_1"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(07)62381-2"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01176-13"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19055-7"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","unstructured":"Ramirez S Fernandez-Antunez C Galli A Underwood A Pham LV Ryberg LA Feng S Pedersen MS Mikkelsen LS Belouzard S Dubuisson J S\u00f8lund C Weis N Gottwein JM Fahn\u00f8e U Bukh J. 2021. Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication. Antimicrob Agents Chemother 65:e00097\u201321. 10.1128\/AAC.00097-21.","DOI":"10.1128\/AAC.00097-21"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0282-0"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0356-z"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18233-x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c01186"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109133"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.009"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02164-12"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01953-15"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02929-15"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.031"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30647"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.004"},{"key":"e_1_3_3_45_2","unstructured":"Zhou Y Glimore K Ramirez S Settles E Gammeltoft KA Pham LV Fahn\u00f8e U Feng S Offersgaard A Trimpert T Bukh J Osterrieder K Gottwein JM Seeberger PH. In vitro efficacy of artemisinin-based treatments against SARS-CoV-2. Sci Rep in press."},{"key":"e_1_3_3_46_2","unstructured":"Chou T-C Martin N. 2007. CompuSyn software for drug combinations and for general dose effect analysis and user\u2019s guide. ComboSyn Inc. Paramus NJ."},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(84)90007-4"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26660"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02698-09"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24172"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006(2007)54[19:DTIDPG]2.0.CO;2"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.055897"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2958"},{"key":"e_1_3_3_54_2","unstructured":"Center for Drug Evaluation and Research. 2009. Clinical pharmacology and biopharmaceuticals review(s). Application number 205123Orig1s000. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2013\/205123Orig1s000ClinPharmR.pdf."},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2196-x"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01058-08"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173634"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112529"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1753577"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1794974"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.2174\/1386207323666200814132149"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.103848"},{"key":"e_1_3_3_63_2","first-page":"341","article-title":"Whole genome analysis and targeted drug discovery using computational methods and high throughput screening tools for emerged novel coronavirus (2019-nCoV)","volume":"3","author":"Manikyam JH","year":"2020","unstructured":"Manikyam JH, Joshi SK. 2020. Whole genome analysis and targeted drug discovery using computational methods and high throughput screening tools for emerged novel coronavirus (2019-nCoV). J Pharm Drug Res 3:341\u2013361.","journal-title":"J Pharm Drug Res"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.2174\/1386207323999200730205447"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.07.007"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20201256"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00521"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1813200"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12040445"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118205"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv.12044538"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128878"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11224-020-01586-w"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1782768"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1796804"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1794971"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74468-0"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv.12153615.V1"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2020.100860"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104451"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1814870"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104359"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70863-9"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.10.007"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-26344\/v1"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16954-7"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.24.13001-13014.2002"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02667-09"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.036"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02680-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02680-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:04:42Z","timestamp":1645466682000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02680-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":89,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,8,17]]}},"alternative-id":["10.1128\/AAC.02680-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.02680-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.12.02.408112","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,17]]},"assertion":[{"value":"2020-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02680-20"}}