{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:12:47Z","timestamp":1762272767158,"version":"3.41.2"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,8,17]]},"abstract":"<jats:p>\n            A series of (\n            <jats:italic>Z<\/jats:italic>\n            )-2-(nitroheteroarylmethylene)-3(2\n            <jats:italic>H<\/jats:italic>\n            )-benzofuranones possessing nitroheteroaryl groups of nitroimidazole, nitrofuran, and nitrothiophene moieties was screened for antiplasmodium activity against a drug-sensitive strain (3D7 strain) and a multidrug-resistant (chloroquine [CQ] and pyrimethamine) strain (K1 strain) of\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            . 5-Nitroimidazole and 4-nitroimidazole analogs were highly selective and active against resistant parasites, while 5-nitrofuran and 5-nitrothiophene derivatives were more potent against the 3D7 strain than against the K1 strain. Among the synthetic analogues, (\n            <jats:italic>Z<\/jats:italic>\n            )-6-chloro-2-(1-methyl-5-nitroimidazol-2-ylmethylene)-3(2\n            <jats:italic>H<\/jats:italic>\n            )-benzofuranone (compound\n            <jats:bold>5h<\/jats:bold>\n            ) exhibited the highest activity (50% inhibitory concentration [IC\n            <jats:sub>50<\/jats:sub>\n            ], 0.654\u2009nM) against the K1 strain and (\n            <jats:italic>Z<\/jats:italic>\n            )-7-methoxy-2-(5-nitrothiophen-2-ylmethylene)-3(2\n            <jats:italic>H<\/jats:italic>\n            )-benzofuranone (\n            <jats:bold>10g<\/jats:bold>\n            ) showed the highest activity (IC\n            <jats:sub>50<\/jats:sub>\n            , 0.28\u2009\u03bcM) against the 3D7 strain in comparison with the activities of CQ (IC\n            <jats:sub>50<\/jats:sub>\n            s of 3.13 and 206.3\u2009nM against 3D7 and K1 strains, respectively).\n          <\/jats:p>","DOI":"10.1128\/aac.02683-20","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T19:27:30Z","timestamp":1625599650000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Antimalarial Activities of (\n            <i>Z<\/i>\n            )-2-(Nitroheteroarylmethylene)-3(2\n            <i>H<\/i>\n            )-Benzofuranone Derivatives:\n            <i>In Vitro<\/i>\n            and\n            <i>In Vivo<\/i>\n            Assessment and \u03b2-Hematin Formation Inhibition Activity"],"prefix":"10.1128","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-0906","authenticated-orcid":true,"given":"Latifeh","family":"Navidpour","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Chibale","sequence":"additional","affiliation":[{"name":"South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch, South Africa"},{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"School of Traditional Medicine, Traditional Medicine &amp; Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh","family":"Ghiaee","sequence":"additional","affiliation":[{"name":"School of Traditional Medicine, Traditional Medicine &amp; Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narges","family":"Hadj-esfandiari","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboubeh","family":"Irani","sequence":"additional","affiliation":[{"name":"School of Traditional Medicine, Traditional Medicine &amp; Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheyda","family":"Ahmadi Koulaei","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narguess","family":"Yassa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"WHO. 2019. The \u201cWorld malaria report 2019\u201d at a glance. World Health Organization Geneva Switzerland. https:\/\/www.who.int\/news-room\/feature-stories\/detail\/world-malaria-report-2019."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0318-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202031"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.11.025"},{"key":"e_1_3_2_6_2","unstructured":"WHO. 2020. Tackling antimalarial drug resistance. Launch of the WHO Report on antimalarial drug efficacy resistance and response: 10 years of surveillance. (2010\u20132019). World Health Organization Geneva Switzerland. https:\/\/www.who.int\/docs\/default-source\/malaria\/drug-resistance\/who-ucn-gmp-2020-07-eng.pdf?sfvrsn=a2c11533_2&download=true."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed4010026"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2724-z"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2020.101765"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1524871"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2015.1000483"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(99)00021-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2015.07.004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.farmac.2005.01.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm058208o"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.09.062"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.16.6.710"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01278.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402433200"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.22037\/IJPR.2018.2223"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51604-z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(67)90015-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1975.11686997"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02683-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02683-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:02:13Z","timestamp":1645484533000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02683-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,8,17]]}},"alternative-id":["10.1128\/AAC.02683-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.02683-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2021,8,17]]},"assertion":[{"value":"2020-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02683-20"}}