{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:11:50Z","timestamp":1771567910858,"version":"3.50.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERESP"],"award-info":[{"award-number":["CIBERESP"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014588","name":"Sanofi US | Sanofi Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014588","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,5,18]]},"abstract":"<jats:p>Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.<\/jats:p>","DOI":"10.1128\/aac.02718-20","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T12:37:21Z","timestamp":1616848641000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019"],"prefix":"10.1128","volume":"65","author":[{"given":"Beatriz","family":"Mengual-Chuli\u00e1","sequence":"first","affiliation":[{"name":"Virology Laboratory, Genomics and Health Area, Centro Superior de Investigaci\u00f3n en Salud P\u00fablica, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Alonso-Cordero","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Genomics and Health Area, Centro Superior de Investigaci\u00f3n en Salud P\u00fablica, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cano","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Genomics and Health Area, Centro Superior de Investigaci\u00f3n en Salud P\u00fablica, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. del Mar","family":"Mosquera","sequence":"additional","affiliation":[{"name":"Microbiology Service, Center of Biomedical Diagnostics, Hospital Cl\u00ednic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"de Molina","sequence":"additional","affiliation":[{"name":"Microbiology Service, Center of Biomedical Diagnostics, Hospital Cl\u00ednic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roser","family":"Vendrell","sequence":"additional","affiliation":[{"name":"Microbiology Service, Center of Biomedical Diagnostics, Hospital Cl\u00ednic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Reyes-Prieto","sequence":"additional","affiliation":[{"name":"Bioinformatics and Sequencing Service, Fundaci\u00f3n para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireia","family":"Jan\u00e9","sequence":"additional","affiliation":[{"name":"Public Health Agency of Catalonia, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Torner","sequence":"additional","affiliation":[{"name":"Public Health Agency of Catalonia, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Isabel","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Public Health Agency of Catalonia, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-3926","authenticated-orcid":true,"given":"Jordi","family":"Vila","sequence":"additional","affiliation":[{"name":"Microbiology Service, Center of Biomedical Diagnostics, Hospital Cl\u00ednic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"D\u00edez-Domingo","sequence":"additional","affiliation":[{"name":"Vaccine Research Area, Centro Superior de Investigaci\u00f3n en Salud P\u00fablica, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. \u00c1ngeles","family":"Marcos","sequence":"additional","affiliation":[{"name":"Microbiology Service, Center of Biomedical Diagnostics, Hospital Cl\u00ednic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Xavier","family":"L\u00f3pez-Labrador","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Genomics and Health Area, Centro Superior de Investigaci\u00f3n en Salud P\u00fablica, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain"},{"name":"CIBERESP, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.981-986.2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.93.027"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm5007275"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2019.24.3.1800666"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1811345115"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.06.007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3212"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy547"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04623-14"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27890-4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Hashimoto T Baba K Inoue K Okane M Hata S Shishido T Naito A Wildum S Omoto S. 24 October 2020. Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil. Influenza Other Respir Viruses https:\/\/doi.org\/10.1111\/irv.12821.","DOI":"10.22541\/au.159284818.81967184"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01109-09"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr026"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr507"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-018-0555-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz245"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2019.24.12.1900170"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz472"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz244"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2511.190757"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"Abed Y Saim-Mamoun A Boivin G. 25 September 2020. Fitness of influenza A and B viruses with reduced susceptibility to baloxavir: a mini-review. Rev Med Virol https:\/\/doi.org\/10.1002\/rmv.2175.","DOI":"10.1002\/rmv.2175"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104828"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa164"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12056"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02718-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02718-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:28:59Z","timestamp":1645486139000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02718-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,5,18]]}},"alternative-id":["10.1128\/AAC.02718-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.02718-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"2020-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02718-20"}}