{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:52:53Z","timestamp":1791834773648,"version":"4.3.4"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.<\/jats:p>","DOI":"10.1128\/aac.02856-14","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T03:36:16Z","timestamp":1399347376000},"page":"4227-4229","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism"],"prefix":"10.1128","volume":"58","author":[{"given":"J. L.","family":"Del Pozo","sequence":"first","affiliation":[{"name":"Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain"},{"name":"Department of Clinical Microbiology, Clinica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fern\u00e1ndez-Ros","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain"},{"name":"Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"S\u00e1ez","sequence":"additional","affiliation":[{"name":"Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain"},{"name":"Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. I.","family":"Herrero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Yuste","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain"},{"name":"Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Banales","sequence":"additional","affiliation":[{"name":"Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain"},{"name":"Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain"},{"name":"Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of Basque Country (UPV), IKERBASQUE (Basque Foundation for Science), San Sebasti\u00e1n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.8.1189"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200301023480123"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2008.12.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.5.771"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.08.010"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/501356"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/430441"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/499533"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-008-7329-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200511243532123"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.20"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-6302-x"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02856-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02856-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:52:15Z","timestamp":1645483935000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02856-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1128\/AAC.02856-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.02856-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"2014-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}