{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:07:55Z","timestamp":1782205675538,"version":"3.54.5"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Vancomycin-resistant enterococci (VRE) are a growing health problem, and uncertainties exist regarding the optimal therapy for bloodstream infection due to VRE. We conducted systematic comparative evaluations of the impact of different antimicrobial therapies on the outcomes of patients with bloodstream infections due to VRE. A retrospective study from January 2008 to October 2010 was conducted at Detroit Medical Center. Unique patients with blood cultures due to VRE were included and reviewed. Three major therapeutic classes were analyzed: daptomycin, linezolid, and \u03b2-lactams. Three multivariate models were conducted for each outcome, matching for a propensity score predicting the likelihood of receipt of one of the therapeutic classes. A total of 225 cases of bacteremia due to VRE were included, including 86 (38.2%) cases of VR\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterococcus faecalis<\/jats:named-content>\n            and 139 (61.8%) of VR\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterococcus faecium<\/jats:named-content>\n            . Bacteremia due to VR\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. faecalis<\/jats:named-content>\n            was more frequent among subjects treated with \u03b2-lactams than among those treated with daptomycin or linezolid. The median dose of daptomycin was 6 mg\/kg of body weight (range, 6 to 12 mg\/kg). After controlling for propensity score and bacteremia due to VR\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. faecalis<\/jats:named-content>\n            , differences in mortality were nonsignificant among the treatment groups. Therapy with daptomycin was associated with higher median variable direct cost per day than that for linezolid. This large study revealed the three therapeutic classes (daptomycin, linezolid, and \u03b2-lactams) are similarly efficacious in the treatment of bacteremia due to susceptible strains of VRE.\n          <\/jats:p>","DOI":"10.1128\/aac.02943-14","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T03:36:16Z","timestamp":1399347376000},"page":"3968-3975","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Impact of Different Antimicrobial Therapies on Clinical and Fiscal Outcomes of Patients with Bacteremia Due to Vancomycin-Resistant Enterococci"],"prefix":"10.1128","volume":"58","author":[{"given":"Kayoko","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"},{"name":"Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily T.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma Mahesh","family":"Gudur","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Marchaim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Dalle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Alshabani","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyan Srinivas","family":"Muppavarapu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fnu","family":"Jaydev","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Bathina","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranathi Rao","family":"Sundaragiri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Dhar","family":"Rajuri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaikumar","family":"Khatri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Pogue","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"},{"name":"Department of Pharmacy Services, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Lephart","sequence":"additional","affiliation":[{"name":"Detroit Medical Center University Laboratories, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rybak","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"},{"name":"Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith S.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir924"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/591861"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/661599"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.6.5.637"},{"key":"e_1_3_3_6_2","volume-title":"Approved standard M100-S19","author":"Clinical and Laboratory Standards Institute","year":"2009","unstructured":"Clinical and Laboratory Standards Institute. 2009. 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