{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:42:56Z","timestamp":1789818176009,"version":"4.0.1"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A novel erythromycin ribosome methylase gene,\n            <jats:italic>erm<\/jats:italic>\n            (44), that confers resistance to macrolide, lincosamide, and streptogramin B (MLS\n            <jats:sub>B<\/jats:sub>\n            ) antibiotics was identified by whole-genome sequencing of the chromosome of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus xylosus<\/jats:named-content>\n            isolated from bovine mastitis milk. The\n            <jats:italic>erm<\/jats:italic>\n            (44) gene is preceded by a regulatory sequence that encodes two leader peptides responsible for the inducible expression of the methylase gene, as demonstrated by cloning in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            . The\n            <jats:italic>erm<\/jats:italic>\n            (44) gene is located on a 53-kb putative prophage designated \u03a6JW4341-pro. The 56 predicted open reading frames of \u03a6JW4341-pro are structurally organized into the five functional modules found in members of the family\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Siphoviridae<\/jats:named-content>\n            . \u03a6JW4341-pro is site-specifically integrated into the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. xylosus<\/jats:named-content>\n            chromosome, where it is flanked by two perfect 19-bp direct repeats, and exhibits the ability to circularize. The presence of\n            <jats:italic>erm<\/jats:italic>\n            (44) in three additional\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. xylosus<\/jats:named-content>\n            strains suggests that this putative prophage has the potential to disseminate MLS\n            <jats:sub>B<\/jats:sub>\n            resistance.\n          <\/jats:p>","DOI":"10.1128\/aac.02949-14","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T03:35:46Z","timestamp":1407209746000},"page":"6133-6138","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["The Novel Macrolide-Lincosamide-Streptogramin B Resistance Gene\n            <i>erm<\/i>\n            (44) Is Associated with a Prophage in Staphylococcus xylosus"],"prefix":"10.1128","volume":"58","author":[{"given":"Juliette R. 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