{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:58:52Z","timestamp":1790276332496,"version":"4.1.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            It is uncertain whether monitoring plasma ganciclovir (GCV) levels is useful in predicting cytomegalovirus (CMV) DNAemia clearance in preemptively treated allogeneic stem cell transplant recipients. In this observational study, including 13 episodes of CMV DNAemia treated with intravenous (i.v.) GCV or oral valganciclovir, we showed that monitoring trough plasma GCV levels does not reliably predict response to therapy. Rather, immunological monitoring (pp65 and immediate-early [IE]-1-specific gamma interferon [IFN-\u03b3]-producing CD8\n            <jats:sup>+<\/jats:sup>\n            T cells) appeared to perform better for this purpose.\n          <\/jats:p>","DOI":"10.1128\/aac.02953-14","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T14:43:52Z","timestamp":1404225832000},"page":"5602-5605","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Monitoring of Trough Plasma Ganciclovir Levels and Peripheral Blood Cytomegalovirus (CMV)-Specific CD8\n            <sup>+<\/sup>\n            T Cells To Predict CMV DNAemia Clearance in Preemptively Treated Allogeneic Stem Cell Transplant Recipients"],"prefix":"10.1128","volume":"58","author":[{"given":"Estela","family":"Gim\u00e9nez","sequence":"first","affiliation":[{"name":"Microbiology Service, Hospital Cl\u00ednico Universitario, Fundaci\u00f3n INCLIVA, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Solano","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Service, Hospital Cl\u00ednico Universitario, Fundaci\u00f3n INCLIVA, Valencia, Spain"},{"name":"Department of Medicine, School of Medicine, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Azanza","sequence":"additional","affiliation":[{"name":"Clinic Pharmacology Service, Cl\u00ednica Universidad de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Amat","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Service, Hospital Cl\u00ednico Universitario, Fundaci\u00f3n INCLIVA, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Navarro","sequence":"additional","affiliation":[{"name":"Microbiology Service, Hospital Cl\u00ednico Universitario, Fundaci\u00f3n INCLIVA, Valencia, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.09.64"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705311"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3786"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.1.188"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00014.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200402000-00014"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0293-y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.172"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21799"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00797-08"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.330"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00666-X"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/48.3.208"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.177"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/340653"},{"key":"e_1_3_2_18_2","first-page":"e257","article-title":"Low systemic ganciclovir exposure and preemptive treatment failure of cytomegalovirus reactivation in a transplanted child","volume":"18","author":"Autmizguine J","year":"2011","unstructured":"AutmizguineJTh\u00e9\u00f4retYLaunayEDuvalMRousseauCTapi\u00e9roBBoivinGOvetchkineP. 2011. 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