{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:30:32Z","timestamp":1777433432435,"version":"3.51.4"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) were employed to determine the chemical composition of the essential oil (EO) from aromatic water (AW) of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Zataria multiflora<\/jats:named-content>\n            . Thymol (66.9%), carvacrol (15.2%), and carvone (7.3%) were found to be the major EO constituents. Eighty laboratory BALB\/c mice were infected intraperitoneally by injection of 1,500 viable protoscolices and were divided into prevention (40 mice) and therapeutic (40 mice) groups. To prove the preventive effect of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Z. multiflora<\/jats:named-content>\n            AW on development of hydatid cysts, the 40 infected mice were allocated into three treatment groups, including the albendazole group (10 mice that received 150 mg\/kg body weight\/day for 10 days), the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Z. multiflora<\/jats:named-content>\n            AW group (15 mice that received 20 ml\/liter in drinking water for 8 months), and a control group (15 mice that received no treatment). To estimate the therapeutic effect of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Z. multiflora<\/jats:named-content>\n            AW on the hydatid cyst, after 8 months of infection, the 15 remaining mice were allocated into three experimental treatment groups of five animals each, including the albendazole group (300 mg\/kg\/day for 20 days),\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Z. multiflora<\/jats:named-content>\n            AW group (40 ml\/liter in drinking water for 30 days), and control group (no treatment). All mice were then euthanized, and the sizes and weights of the cysts as well as their ultrastructural changes were investigated. The weights and sizes of the hydatid cysts significantly decreased upon treatment with the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Z. multiflora<\/jats:named-content>\n            AW in both the preventive and therapeutic groups (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). The results of scanning electron microscopy also showed considerable damage in the germinal layer of the hydatid cysts recovered from the treated animals.\n          <\/jats:p>","DOI":"10.1128\/aac.02963-14","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T06:34:28Z","timestamp":1406615668000},"page":"6003-6008","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["<i>In Vivo<\/i>\n            Study of the Efficacy of the Aromatic Water of Zataria multiflora on Hydatid Cysts"],"prefix":"10.1128","volume":"58","author":[{"given":"Mohammad","family":"Moazeni","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Larki","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Jamal","family":"Saharkhiz","sequence":"additional","affiliation":[{"name":"Department of Horticulture Science, Faculty of Agriculture, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Oryan","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Ansary Lari","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Food Quality Control, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Mootabi Alavi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(03)00198-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-007-3796-x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00130-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70134-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000524"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.2008.79.301","article-title":"Clinical management of cystic echinococcosis: state of the art, problems, and perspectives","volume":"79","author":"Junghanss T","year":"2008","unstructured":"JunghanssTMenezes da SilvaAHortonJChiodiniPLBrunettiE. 2008. 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