{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T11:17:22Z","timestamp":1782040642924,"version":"3.54.5"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We investigated the activity of trimethoprim-sulfamethoxazole (SXT) against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium tuberculosis<\/jats:named-content>\n            , the pathogen that causes tuberculosis (TB). The MIC distribution of SXT was 0.125\/2.4 to 2\/38 mg\/liter for the 100 isolates tested, including multi- and extensively drug-resistant isolates (MDR\/XDR-TB), whereas the intracellular MIC\n            <jats:sub>90<\/jats:sub>\n            of sulfamethoxazole (SMX) for the pansusceptible strain H37Rv was 76 mg\/liter. In an exploratory analysis using a ratio of the unbound area under the concentration-time curve from 0 to 24 h over MIC (\n            <jats:italic>f<\/jats:italic>\n            AUC\n            <jats:sub>0\u201324<\/jats:sub>\n            \/MIC) using \u226525 as a potential target, the cumulative fraction response was \u226590% at doses of \u22652,400 mg of SMX. SXT is a potential treatment option for MDR\/XDR-TB.\n          <\/jats:p>","DOI":"10.1128\/aac.02995-14","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T05:05:57Z","timestamp":1411448757000},"page":"7557-7559","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Intra- and Extracellular Activities of Trimethoprim-Sulfamethoxazole against Susceptible and Multidrug-Resistant Mycobacterium tuberculosis"],"prefix":"10.1128","volume":"58","author":[{"given":"L.","family":"Davies Forsman","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Infectious Diseases, Karolinska University Hospital Solna, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Link\u00f6ping University Hospital, Link\u00f6ping, Sweden"},{"name":"Department of Medicine and Optometry, Linnaeus University, Kalmar, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. S. H.","family":"Simonsson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bruchfeld","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Infectious Diseases, Karolinska University Hospital Solna, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Link\u00f6ping University Hospital, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jur\u00e9en","sequence":"additional","affiliation":[{"name":"Unit for Highly Pathogenic Bacteria, Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Stureg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Regional and University Laboratories, Region Sk\u00e5ne, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. G.","family":"Giske","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, MTC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"\u00c4ngeby","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, MTC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Microbiology, The University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2014.02.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01658-08"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00029-10"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/42.6.811"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr501"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00832-12"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks306"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00876-10"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01683-13"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki079"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp262"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00446-09"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114812"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01301-08"},{"issue":"16","key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"pii=19846","DOI":"10.2807\/ese.16.16.19846-en","article-title":"Imported extensively drug-resistant Mycobacterium tuberculosis Beijing genotype, Marseilles, France, 2011","volume":"16","author":"Cohen-Bacrie S","year":"2011","unstructured":"Cohen-BacrieSBen KahlaIBotelho-NeversEMillionMParolaPBrouquiPDrancourtM. 2011. Imported extensively drug-resistant Mycobacterium tuberculosis Beijing genotype, Marseilles, France, 2011. Euro Surveill. 16(16):pii=19846. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=19846.","journal-title":"Euro Surveill."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.24.6.976-981.1986"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.07.011"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02995-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.02995-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:46:40Z","timestamp":1645483600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.02995-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1128\/AAC.02995-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.02995-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"2014-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}