{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:10:55Z","timestamp":1761217855674,"version":"3.37.3"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104-2320-B-010-023-MY3"],"award-info":[{"award-number":["104-2320-B-010-023-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Professor Tsuei-Chu Mong Merit Scholarship","award":["30219003"],"award-info":[{"award-number":["30219003"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Stenotrophomonas maltophilia<\/jats:named-content>\n            harbors six lytic transglycosylases (LTs):\n            <jats:italic>mltA<\/jats:italic>\n            ,\n            <jats:italic>mltB1<\/jats:italic>\n            ,\n            <jats:italic>mltB2<\/jats:italic>\n            ,\n            <jats:italic>mltD1<\/jats:italic>\n            ,\n            <jats:italic>mltD2<\/jats:italic>\n            , and\n            <jats:italic>slt<\/jats:italic>\n            . LT deletion increased susceptibility of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. maltophilia<\/jats:named-content>\n            to aminoglycosides (AGs) and macrolides, and the underlying mechanisms were investigated. The expression of AG-modifying enzymes and efflux pumps was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Susceptibility to 1-\n            <jats:italic>N<\/jats:italic>\n            -phenylnaphthylamine, vancomycin, SDS, and bile salts was measured to assess outer membrane permeability. In conclusion, increased outer membrane permeability contributes to LT deletion-mediated increase in aminoglycoside and macrolide susceptibility.\n          <\/jats:p>","DOI":"10.1128\/aac.03026-15","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T02:49:37Z","timestamp":1458010177000},"page":"3236-3239","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Inactivation of Lytic Transglycosylases Increases Susceptibility to Aminoglycosides and Macrolides by Altering the Outer Membrane Permeability of Stenotrophomonas maltophilia"],"prefix":"10.1128","volume":"60","author":[{"given":"Chao-Jung","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Tsung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuey-Ching","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"doi-asserted-by":"publisher","key":"e_1_3_3_2_2","DOI":"10.1007\/s00018-003-3056-1"},{"doi-asserted-by":"publisher","key":"e_1_3_3_3_2","DOI":"10.1128\/AAC.00268-13"},{"doi-asserted-by":"publisher","key":"e_1_3_3_4_2","DOI":"10.3389\/fmicb.2015.00893"},{"doi-asserted-by":"publisher","key":"e_1_3_3_5_2","DOI":"10.1186\/gb-2008-9-4-r74"},{"doi-asserted-by":"publisher","key":"e_1_3_3_6_2","DOI":"10.1128\/AAC.05179-14"},{"key":"e_1_3_3_7_2","volume-title":"M100-S20","author":"Clinical and Laboratory Standards Institute","year":"2010","unstructured":"Clinical and Laboratory Standards Institute. 2010. 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