{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:01:44Z","timestamp":1761541304042},"reference-count":21,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Structure-activity relationship studies of trifluoromethyl-substituted pyridine and pyrimidine analogues of 2-aminomethylphenols (JPC-2997, JPC-3186, and JPC-3210) were conducted for preclinical development for malaria treatment and\/or prevention. Of these compounds, JPC-3210 [4-(\n            <jats:italic>tert<\/jats:italic>\n            -butyl)-2-((\n            <jats:italic>tert<\/jats:italic>\n            -butylamino)methyl)-6-(5-fluoro-6-(trifluoromethyl)pyridin-3-yl)phenol] was selected as the lead compound due to superior\n            <jats:italic>in vitro<\/jats:italic>\n            antimalarial activity against multidrug-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            lines, lower\n            <jats:italic>in vitro<\/jats:italic>\n            cytotoxicity in mammalian cell lines, longer plasma elimination half-life, and greater\n            <jats:italic>in vivo<\/jats:italic>\n            efficacy against murine malaria.\n          <\/jats:p>","DOI":"10.1128\/aac.03066-15","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T04:33:28Z","timestamp":1454992408000},"page":"3115-3118","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention"],"prefix":"10.1128","volume":"60","author":[{"given":"Marina","family":"Chavchich","sequence":"first","affiliation":[{"name":"Department of Drug Evaluation, Australian Army Malaria Institute, Enoggera, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey W.","family":"Birrell","sequence":"additional","affiliation":[{"name":"Department of Drug Evaluation, Australian Army Malaria Institute, Enoggera, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arba L.","family":"Ager","sequence":"additional","affiliation":[{"name":"University of Miami, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna O.","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Department of Drug Evaluation, Australian Army Malaria Institute, Enoggera, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin D.","family":"Heffernan","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company, Princeton, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy A.","family":"Schiehser","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company, Princeton, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura R.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company, Princeton, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Dennis","family":"Shanks","sequence":"additional","affiliation":[{"name":"Department of Drug Evaluation, Australian Army Malaria Institute, Enoggera, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company, Princeton, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Edstein","sequence":"additional","affiliation":[{"name":"Department of Drug Evaluation, Australian Army Malaria Institute, Enoggera, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 2014. World malaria report 2014. 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