{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:30:30Z","timestamp":1789893030554,"version":"4.0.1"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We investigated the impact of the hatchery practice of administering third-generation cephalosporin (3GC) on the selection and persistence of 3GC-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            in poultry. We studied 15 3GC-treated (TB) and 15 non-3GC-treated (NTB) broiler flocks and 12 3GC-treated (TL) and 10 non-3GC-treated (NTL) future layer flocks. Fecal samples from each flock were sampled before arrival on the farm (day 0), on day 2, on day 7, and then twice more.\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            isolates were isolated on MacConkey agar without antibiotics and screened for 3GC resistance, and any 3GC-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            isolates were further analyzed. 3GC-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            isolates were found in all 3GC-treated flocks on at least one sampling date. The percentages of 3GC-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            isolates were significantly higher in TB (41.5%) than in NTB (19.5%) flocks and in TL (49.5%) than in NTL (24.5%) flocks. In the day 2 samples, more than 80% of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            strains isolated were 3GC resistant. 3GC-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            strains were still detected at the end of the follow-up period in 6 out of 27 3GC-treated and 5 out of 25 non-3GC-treated flocks. Many 3GC-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            strains were resistant to tetracycline, and there were significant differences in the percentages of resistance to sulfamethoxazole-trimethoprim, streptomycin, or gentamicin between treated and nontreated flocks.\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CMY-2<\/jats:sub>\n            were the most frequently detected genes. These results clearly demonstrated that 3GC-resistant strains are introduced early in flocks and that the use of 3GC in hatcheries promotes the selection of 3GC-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            . Measures must be implemented to avoid the spread and selection of 3GC-resistant strains.\n          <\/jats:p>","DOI":"10.1128\/aac.03106-14","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T14:43:52Z","timestamp":1404225832000},"page":"5428-5434","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["Impact of Third-Generation-Cephalosporin Administration in Hatcheries on Fecal Escherichia coli Antimicrobial Resistance in Broilers and Layers"],"prefix":"10.1128","volume":"58","author":[{"given":"Sandrine","family":"Baron","sequence":"first","affiliation":[{"name":"ANSES, Ploufragan Laboratory, Ploufragan, France"},{"name":"Universit\u00e9 Europ\u00e9enne de Bretagne, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jouy","sequence":"additional","affiliation":[{"name":"ANSES, Ploufragan Laboratory, Ploufragan, France"},{"name":"Universit\u00e9 Europ\u00e9enne de Bretagne, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Larvor","sequence":"additional","affiliation":[{"name":"ANSES, Ploufragan Laboratory, Ploufragan, France"},{"name":"Universit\u00e9 Europ\u00e9enne de Bretagne, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Eono","sequence":"additional","affiliation":[{"name":"ANSES, Ploufragan Laboratory, Ploufragan, France"},{"name":"Universit\u00e9 Europ\u00e9enne de Bretagne, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Bougeard","sequence":"additional","affiliation":[{"name":"ANSES, Ploufragan Laboratory, Ploufragan, France"},{"name":"Universit\u00e9 Europ\u00e9enne de Bretagne, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Kempf","sequence":"additional","affiliation":[{"name":"ANSES, Ploufragan Laboratory, Ploufragan, France"},{"name":"Universit\u00e9 Europ\u00e9enne de Bretagne, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2011.12.034"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2011.2322"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.02.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/79.11.1524"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2013.814076"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810001524"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1601.090729"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2010.0036"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.57.4.1013-1017.1991"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2010.0036"},{"key":"e_1_3_2_13_2","unstructured":"EUCAST. 2014. 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