{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:46:57Z","timestamp":1771512417439,"version":"3.50.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our\n            <jats:italic>in vitro<\/jats:italic>\n            combination studies showed that isavuconazole and micafungin are synergistically active against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus fumigatus<\/jats:named-content>\n            ,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus flavus<\/jats:named-content>\n            ,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus terreus<\/jats:named-content>\n            , and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Cunninghamella bertholletiae<\/jats:named-content>\n            . These results suggest that isavuconazole, in combination with micafungin, may have a role in the treatment of invasive aspergillosis and warrants further investigation.\n          <\/jats:p>","DOI":"10.1128\/aac.03261-14","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T05:54:44Z","timestamp":1408427684000},"page":"6934-6937","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["<i>In Vitro<\/i>\n            Combination of Isavuconazole with Micafungin or Amphotericin B Deoxycholate against Medically Important Molds"],"prefix":"10.1128","volume":"58","author":[{"given":"Aspasia","family":"Katragkou","sequence":"first","affiliation":[{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Meletiadis","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidmantas","family":"Petraitis","sequence":"additional","affiliation":[{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patriss W.","family":"Moradi","sequence":"additional","affiliation":[{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gittel E.","family":"Strauss","sequence":"additional","affiliation":[{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique M.","family":"Fouant","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Kovanda","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Petraitiene","sequence":"additional","affiliation":[{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Roilides","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration Hospital, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA"},{"name":"Department of Pediatrics, Weill Cornell Medical College of Cornell University, New York, New York, USA"},{"name":"Department of Microbiology and Immunology, Weill Cornell Medical College of Cornell University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study","volume":"91","author":"Pagano L","year":"2006","unstructured":"PaganoLCairaMCandoniAOffidaniMFianchiLMartinoBPastoreDPicardiMBoniniAChierichiniAFanciRCaramattiCInvernizziRMatteiDMitraMEMelilloLAversaFVan LintMTFalcucciPValentiniCGGirmeniaCNosariA. 2006. 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