{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:33:10Z","timestamp":1765438390027},"reference-count":42,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Coadministration of dihydroartemisinin-piperaquine (DHA-PQ) with fat may improve bioavailability and antimalarial efficacy, but it might also increase toxicity. There have been no studies of these potential effects in the pediatric age group. The tolerability, safety, efficacy, and pharmacokinetics of DHA-PQ administered with or without 8.5 g fat were investigated in 30 Papua New Guinean children aged 5 to 10 years diagnosed with uncomplicated falciparum malaria. Three daily 2.5:11.5-mg-base\/kg doses were given with water (\n            <jats:italic>n<\/jats:italic>\n            = 14, group A) or milk (\n            <jats:italic>n<\/jats:italic>\n            = 16, group B), with regular clinical\/laboratory assessment and blood sampling over 42 days. Plasma PQ was assayed by high-performance liquid chromatography with UV detection, and DHA was assayed using liquid chromatography-mass spectrometry. Compartmental pharmacokinetic models for PQ and DHA were developed using a population-based approach. DHA-PQ was generally well tolerated, and initial fever and parasite clearance were prompt. There were no differences in the areas under the concentration-time curve (AUC\n            <jats:sub>0\u2013\u221e<\/jats:sub>\n            ) for PQ (median, 41,906 versus 36,752 \u03bcg \u00b7 h\/liter in groups A and B, respectively;\n            <jats:italic>P<\/jats:italic>\n            = 0.24) or DHA (4,047 versus 4,190 \u03bcg \u00b7 h\/liter;\n            <jats:italic>P<\/jats:italic>\n            = 0.67). There were also no significant between-group differences in prolongation of the corrected electrocardiographic QT interval (QT\n            <jats:sub>c<\/jats:sub>\n            ) initially during follow-up, but the QT\n            <jats:sub>c<\/jats:sub>\n            tended to be higher in group B children at 24 h (mean \u00b1 standard deviation [SD], 15 \u00b1 10 versus 6 \u00b1 15 ms\n            <jats:sup>0.5<\/jats:sup>\n            in group A,\n            <jats:italic>P<\/jats:italic>\n            = 0.067) and 168 h (10 \u00b1 18 versus 1 \u00b1 23 ms\n            <jats:sup>0.5<\/jats:sup>\n            ,\n            <jats:italic>P<\/jats:italic>\n            = 0.24) when plasma PQ concentrations were relatively low. A small amount of fat does not change the bioavailability of DHA-PQ in children, but a delayed persistent effect on ventricular repolarization cannot be excluded.\n          <\/jats:p>","DOI":"10.1128\/aac.03314-14","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T03:15:21Z","timestamp":1405998921000},"page":"5784-5794","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Effect of Coadministered Fat on the Tolerability, Safety, and Pharmacokinetic Properties of Dihydroartemisinin-Piperaquine in Papua New Guinean Children with Uncomplicated Malaria"],"prefix":"10.1128","volume":"58","author":[{"given":"B. R.","family":"Moore","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia, Australia"},{"name":"Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Salman","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ginny","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Page-Sharp","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Curtin University of Technology, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. J.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea"},{"name":"Infection and Immunity, Walter and Eliza Hall Institute, Melbourne, Victoria, Australia"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Siba","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. T.","family":"Batty","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Curtin University of Technology, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Infection and Immunity, Walter and Eliza Hall Institute, Melbourne, Victoria, Australia"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Center de Recerca en Salut Internacional de Barcelona (CRESIB), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. M. E.","family":"Davis","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010927"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804915"},{"key":"e_1_3_2_4_2","volume-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"2010","unstructured":"World Health Organization. 2010. WHO Global Malaria Programme. Guidelines for the treatment of malaria. 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