{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:59:24Z","timestamp":1790488764825,"version":"4.1.0"},"reference-count":67,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The involvement of\n            <jats:italic>Pfmdr1<\/jats:italic>\n            (\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            multidrug resistance 1) polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the association between polymorphisms in\n            <jats:italic>Pfmdr1<\/jats:italic>\n            (N86Y, Y184F, S1034C, N1042D, and D1246Y) and\n            <jats:italic>Pfcrt<\/jats:italic>\n            (K76T) and\n            <jats:italic>in vitro<\/jats:italic>\n            responses to chloroquine (CQ), mefloquine (MQ), lumefantrine (LMF), quinine (QN), monodesethylamodiaquine (MDAQ), and dihydroartemisinin (DHA) in 174\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            isolates from Dakar, Senegal. The\n            <jats:italic>Pfmdr1<\/jats:italic>\n            86Y mutation was identified in 14.9% of the samples, and the 184F mutation was identified in 71.8% of the isolates. No 1034C, 1042N, or 1246Y mutations were detected. The\n            <jats:italic>Pfmdr1<\/jats:italic>\n            86Y mutation was significantly associated with increased susceptibility to MDAQ (\n            <jats:italic>P<\/jats:italic>\n            = 0.0023), LMF (\n            <jats:italic>P<\/jats:italic>\n            = 0.0001), DHA (\n            <jats:italic>P<\/jats:italic>\n            = 0.0387), and MQ (\n            <jats:italic>P<\/jats:italic>\n            = 0.00002). The N86Y mutation was not associated with CQ (\n            <jats:italic>P<\/jats:italic>\n            = 0.214) or QN (\n            <jats:italic>P<\/jats:italic>\n            = 0.287) responses. The\n            <jats:italic>Pfmdr1<\/jats:italic>\n            184F mutation was not associated with various susceptibility responses to the 6 antimalarial drugs (\n            <jats:italic>P<\/jats:italic>\n            = 0.168 for CQ, 0.778 for MDAQ, 0.324 for LMF, 0.961 for DHA, 0.084 for QN, and 0.298 for MQ). The\n            <jats:italic>Pfmdr1<\/jats:italic>\n            86Y-Y184 haplotype was significantly associated with increased susceptibility to MDAQ (\n            <jats:italic>P<\/jats:italic>\n            = 0.0136), LMF (\n            <jats:italic>P<\/jats:italic>\n            = 0.0019), and MQ (\n            <jats:italic>P<\/jats:italic>\n            = 0.0001). The additional\n            <jats:italic>Pfmdr1<\/jats:italic>\n            86Y mutation increased significantly the\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibility to MDAQ (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001), LMF (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001), MQ (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001), and QN (\n            <jats:italic>P<\/jats:italic>\n            = 0.0026) in wild-type\n            <jats:italic>Pfcrt<\/jats:italic>\n            K76 parasites. The additional\n            <jats:italic>Pfmdr1<\/jats:italic>\n            86Y mutation significantly increased the\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibility to CQ (\n            <jats:italic>P<\/jats:italic>\n            = 0.0179) in\n            <jats:italic>Pfcrt<\/jats:italic>\n            76T CQ-resistant parasites.\n          <\/jats:p>","DOI":"10.1128\/aac.03494-14","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T03:22:56Z","timestamp":1410232976000},"page":"7032-7040","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Role of\n            <i>Pfmdr1<\/i>\n            in\n            <i>In Vitro<\/i>\n            Plasmodium falciparum Susceptibility to Chloroquine, Quinine, Monodesethylamodiaquine, Mefloquine, Lumefantrine, and Dihydroartemisinin"],"prefix":"10.1128","volume":"58","author":[{"given":"Nathalie","family":"Wurtz","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Parasitologie, D\u00e9partement d'Infectiologie de Terrain, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Marseille, France"},{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9caye","family":"Fall","sequence":"additional","affiliation":[{"name":"Laboratoire d'Etude de la Chimiosensibilit\u00e9 du Paludisme, F\u00e9d\u00e9ration des Laboratoires, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Pascual","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie, D\u00e9partement d'Infectiologie de Terrain, Institut de 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