{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:18:36Z","timestamp":1788347916635,"version":"build-2803163510"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The mechanisms of drug resistance development in the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms of\n            <jats:italic>Pfmspdbl2<\/jats:italic>\n            for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (\n            <jats:italic>P<\/jats:italic>\n            = 0.04). The high frequency of\n            <jats:italic>Pfmspdbl2<\/jats:italic>\n            codon 591S in Kenya may be driven by the widespread use of lumefantrine in artemisinin combination therapy (Coartem).\n          <\/jats:p>","DOI":"10.1128\/aac.03522-14","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T03:11:33Z","timestamp":1419304293000},"page":"1770-1775","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine\n            <i>In Vitro<\/i>\n            Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya"],"prefix":"10.1128","volume":"59","author":[{"given":"Lynette Isabella","family":"Ochola-Oyier","sequence":"first","affiliation":[{"name":"Kenya Medical Research Institute\/Wellcome Trust Collaborative Research Program, Kilifi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Okombo","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\/Wellcome Trust Collaborative Research Program, Kilifi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Mwai","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\/Wellcome Trust Collaborative Research Program, Kilifi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Kiara","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\/Wellcome Trust Collaborative Research Program, Kilifi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewa","family":"Pole","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\/Wellcome Trust Collaborative Research Program, Kilifi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K. A.","family":"Tetteh","sequence":"additional","affiliation":[{"name":"Department of Immunology &amp; Infection, Faculty of Infectious &amp; Tropical Diseases, London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Nzila","sequence":"additional","affiliation":[{"name":"King Fahd University of Petroleum and Minerals, Department of Biology, Dhahran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Marsh","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\/Wellcome Trust Collaborative Research Program, Kilifi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Malaria: country antimalarial drug policies: by region","author":"WHO","year":"2013","unstructured":"WHO. 2013. Malaria: country antimalarial drug policies: by region. WHO, Geneva, Switzerland. http:\/\/www.who.int\/malaria\/am_drug_policies_by_region_searo\/en\/index.html."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/427997"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2007.01843.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.5.1893-1895.2006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00875-06"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00968-08"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00638-09"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/596738"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/444460"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02574-12"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005410"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02834.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.350504"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00325-10"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6973.170"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(97)00067-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2321-2328.2004"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.2.418"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/503423"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks252"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msq119"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.03522-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.03522-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:52:54Z","timestamp":1645483974000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.03522-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1128\/AAC.03522-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.03522-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"2014-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}