{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:42:44Z","timestamp":1791308564998,"version":"4.3.1"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n                    <jats:italic>Pfcrt<\/jats:italic>\n                    -76 and\n                    <jats:italic>Pfmdr<\/jats:italic>\n                    1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of\n                    <jats:italic>Pfcrt<\/jats:italic>\n                    -K76 was observed after exposure to AL and DHA-PPQ, as well as selection of\n                    <jats:italic>Pfmdr<\/jats:italic>\n                    1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the\n                    <jats:italic>Pfcrt<\/jats:italic>\n                    gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.\n                  <\/jats:p>","DOI":"10.1128\/aac.03647-14","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:07:10Z","timestamp":1416269230000},"page":"734-737","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["<i>In Vivo<\/i>\n                    Selection of Plasmodium falciparum\n                    <i>Pfcrt<\/i>\n                    and\n                    <i>Pfmdr1<\/i>\n                    Variants by Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine in Burkina Faso"],"prefix":"10.1128","volume":"59","author":[{"given":"Vito","family":"Baraka","sequence":"first","affiliation":[{"name":"National Institute for Medical Research, Tanga Medical Research Centre, Tanga, United Republic of Tanzania"},{"name":"International Health Unit, Department of Epidemiology, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halidou","family":"Tinto","sequence":"additional","affiliation":[{"name":"Centre Muraz, Bobo Dioulasso, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocent","family":"Valea","sequence":"additional","affiliation":[{"name":"Centre Muraz, Bobo Dioulasso, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fitzhenry","sequence":"additional","affiliation":[{"name":"Malariology Unit, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Delgado-Ratto","sequence":"additional","affiliation":[{"name":"International Health Unit, Department of Epidemiology, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Mbonye","sequence":"additional","affiliation":[{"name":"International Health Unit, Department of Epidemiology, University of Antwerp, Antwerp, Belgium"},{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Van Overmeir","sequence":"additional","affiliation":[{"name":"Malariology Unit, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rosanas-Urgell","sequence":"additional","affiliation":[{"name":"Malariology Unit, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Van geertruyden","sequence":"additional","affiliation":[{"name":"International Health Unit, Department of Epidemiology, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"D'Alessandro","sequence":"additional","affiliation":[{"name":"Malariology Unit, Institute of Tropical Medicine, Antwerp, Belgium"},{"name":"Medical Research Council, Banjul, the Gambia"},{"name":"London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Erhart","sequence":"additional","affiliation":[{"name":"Malariology Unit, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"e_1_3_2_4_2","volume-title":"Status report on artemisinin resistance","author":"WHO","year":"2014","unstructured":"WHO. 2014. 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