{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:50:22Z","timestamp":1791283822885,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Antibiotics disrupt the intestinal microbiota, rendering patients vulnerable to colonization by exogenous pathogens. Intermicrobial interactions may attenuate this effect. Incubation with ceftriaxone-resistant,\n            <jats:italic>ccrA<\/jats:italic>\n            -positive, \u03b2-lactamase-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacteroides<\/jats:named-content>\n            strains raised the minimum bactericidal concentration of ceftriaxone required to kill a susceptible\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            strain (mean change, &lt;0.25 to 29 mg\/liter;\n            <jats:italic>P<\/jats:italic>\n            = 0.009); incubation with ceftriaxone-resistant but non-\u03b2-lactamase-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacteroides<\/jats:named-content>\n            strains had no effect. The production of \u03b2-lactamase by common members of the intestinal microbiota (\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacteroides<\/jats:named-content>\n            ) can protect susceptible fellow commensals from \u03b2-lactams.\n          <\/jats:p>","DOI":"10.1128\/aac.03719-14","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T07:44:04Z","timestamp":1412667844000},"page":"650-653","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Metallo-\u03b2-Lactamase-Producing Bacteroides Species Can Shield Other Members of the Gut Microbiota from Antibiotics"],"prefix":"10.1128","volume":"59","author":[{"given":"Usha","family":"Stiefel","sequence":"first","affiliation":[{"name":"Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA"},{"name":"Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Tima","sequence":"additional","affiliation":[{"name":"Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Nerandzic","sequence":"additional","affiliation":[{"name":"Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.3.409"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00066-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432604"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/379153"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5190-5191.2005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn298"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg095"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02782-14"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.11.2391"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.8.1711"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg221"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.5.2584-2593.1990"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00778-06"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.1.4.283"},{"key":"e_1_3_2_16_2","volume-title":"NCCLS document M11-A8","author":"National Committee for Clinical Laboratory Standards","year":"2012","unstructured":"National Committee for Clinical Laboratory Standards. 2012. 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