{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:06:41Z","timestamp":1780106801639,"version":"3.54.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The effects of doxycycline-streptomycin-rifampin versus a standard doxycycline-streptomycin regimen on residual\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            DNA were compared in 36 acute brucellosis patients. At admission, all patients given triple (\n            <jats:italic>n<\/jats:italic>\n            = 22) and double (\n            <jats:italic>n<\/jats:italic>\n            = 14) regimens had detectable\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            DNA with similar mean loads (\n            <jats:italic>P<\/jats:italic>\n            = 0.982). At follow-up, 14 to 20 months postpresentation, significantly more patients receiving triple than double regimens had undetectable\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            DNA (\n            <jats:italic>P<\/jats:italic>\n            = 0.026). The doxycycline-streptomycin-rifampin regimen eliminates\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            DNA more efficiently than doxycycline-streptomycin, which may result in superior long-term clearance of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.03841-14","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T05:05:57Z","timestamp":1411448757000},"page":"7541-7544","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Administration of a Triple versus a Standard Double Antimicrobial Regimen for Human Brucellosis More Efficiently Eliminates Bacterial DNA Load"],"prefix":"10.1128","volume":"58","author":[{"given":"Georgia","family":"Vrioni","sequence":"first","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adamantios","family":"Bourdakis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Trikala General Hospital, Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Pappas","sequence":"additional","affiliation":[{"name":"Institute of Continuing Medical Education of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Pitiriga","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mavrouli","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Pournaras","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Tsakris","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050570"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.06.013"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70382-6"},{"key":"e_1_3_2_5_2","volume-title":"Epidemiological data for brucellosis in Greece (mandatory notification system)","author":"Department of Epidemiological Surveillance and Intervention","year":"2010","unstructured":"Department of Epidemiological Surveillance and Intervention. 2010. Epidemiological data for brucellosis in Greece (mandatory notification system). Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Ministry of Health, Maroussi, Greece. http:\/\/www.keelpno.gr. Accessed 9 March 2013."},{"key":"e_1_3_2_6_2","first-page":"56","volume-title":"Annual epidemiological report on communicable diseases in Europe 2011","author":"European Centre for Disease Prevention and Control","year":"2010","unstructured":"European Centre for Disease Prevention and Control. 2010. Brucellosis, p 56\u201358. In Annual epidemiological report on communicable diseases in Europe 2011. 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