{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:33:01Z","timestamp":1761129181505},"reference-count":23,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background antibiotic use (i.e., administration of antibiotics not directly related to\n Chlamydia trachomatis<\/jats:named-content>\n or\n Neisseria gonorrhoeae<\/jats:named-content>\n infections) has been associated with a lower prevalence of genital\n C. trachomatis<\/jats:named-content>\n infection in a clinical setting. Associations with specific antibiotic types or with\n N. gonorrhoeae<\/jats:named-content>\n are lacking. Here, we assessed the prevalence of antibiotic use, the different classes and agents used, and their association with a subsequent sexually transmitted infection (STI) clinic\n C. trachomatis<\/jats:named-content>\n and\n N. gonorrhoeae<\/jats:named-content>\n test result. At our STI clinic, we systematically registered whether antibiotics were used in the past month (in 29% of the cases, the specific antibiotic agent was named). Patients were screened for urogenital\n C. trachomatis<\/jats:named-content>\n and\n N. gonorrhoeae<\/jats:named-content>\n ; a third of them were also screened for anorectal and oropharyngeal\n C. trachomatis<\/jats:named-content>\n and\n N. gonorrhoeae<\/jats:named-content>\n . The proportion of antibiotics used and their association with\n C. trachomatis<\/jats:named-content>\n and\n N. gonorrhoeae<\/jats:named-content>\n prevalence were assessed for heterosexual men, men who have sex with men (MSM), and women. During 14,775 clinic consultations, antibiotic use was reported by 12.2% (95% confidence interval [CI], 11.7% to 12.7%), i.e., 14.8% of women, 8.6% of heterosexual men, and 11.6% of MSM. The most reported antibiotics were penicillins, tetracyclines, and macrolides, respectively. The prevalence was 11.0% (95% CI, 10.3% to 11.3%) for\n C. trachomatis<\/jats:named-content>\n and 1.9% (95% CI, 1.7% to 2.1%) for\n N. gonorrhoeae<\/jats:named-content>\n . Only tetracycline use was associated with a lower\n C. trachomatis<\/jats:named-content>\n prevalence (3%). Overall antibiotic use was associated with lower anorectal\n C. trachomatis<\/jats:named-content>\n prevalence in MSM only (odds ratio, 0.4; 95% CI, 0.2 to 0.8). STI clinic visitors commonly report recent antibiotic use. Even in a country with low antibiotic consumption, tetracycline use impacted\n C. trachomatis<\/jats:named-content>\n prevalence, while there was a notable absence of association with azithromycin.\n <\/jats:p>","DOI":"10.1128\/aac.03932-14","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T03:23:42Z","timestamp":1413257022000},"page":"121-128","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Antibiotic Use before Chlamydia and Gonorrhea Genital and Extragenital Screening in the Sexually Transmitted Infection Clinical Setting"],"prefix":"10.1128","volume":"59","author":[{"given":"Nicole H. T. M.","family":"Dukers-Muijrers","sequence":"first","affiliation":[{"name":"Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, the Netherlands"},{"name":"Department of Medical Microbiology, School of Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve A. F. S.","family":"van Liere","sequence":"additional","affiliation":[{"name":"Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, the Netherlands"},{"name":"Department of Medical Microbiology, School of Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra F. G.","family":"Wolffs","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper","family":"Den Heijer","sequence":"additional","affiliation":[{"name":"Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita I. L. S.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian J. P. A.","family":"Hoebe","sequence":"additional","affiliation":[{"name":"Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, the Netherlands"},{"name":"Department of Medical Microbiology, School of Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.6.726"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70161-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60604-2"},{"key":"e_1_3_2_5_2","volume-title":"Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae","author":"World Health Organization","year":"2012","unstructured":"World Health Organization. 2012. Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001598"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws583"},{"key":"e_1_3_2_8_2","first-page":"45","article-title":"STD treatment guidelines","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","unstructured":"Centers for Disease Control and Prevention. 2010. STD treatment guidelines. MMWR Recomm Rep 59:45.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_2_9_2","volume-title":"British Association for Sexual Health and HIV","author":"British Association for Sexual Health and HIV","year":"2010","unstructured":"British Association for Sexual Health and HIV. 2010. Chlamydia trachomatis UK testing guidelines. British Association for Sexual Health and HIV, Macclesfield, Cheshire, England. http:\/\/www.bashh.org\/documents\/3352.pdf."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0002-9378(80)91077-7","article-title":"Incidence, prevalence, and trends of acute pelvic inflammatory disease and its consequences in industrialized countries","volume":"138","author":"Westrom L","year":"1980","unstructured":"Westrom L. 1980. Incidence, prevalence, and trends of acute pelvic inflammatory disease and its consequences in industrialized countries. Am J Obstet Gynecol 138:880\u2013892.","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181b12765"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1071\/SH06013"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl188"},{"key":"e_1_3_2_14_2","volume-title":"Surveillance of antimicrobial consumption in Europe 2011","author":"European Centre for Disease Prevention and Control","year":"2014","unstructured":"European Centre for Disease Prevention and Control. 2014. Surveillance of antimicrobial consumption in Europe 2011. ECDC, Stockholm, Sweden."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp035"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037778"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.030700"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1258\/095646207781024810"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1086\/314625","article-title":"Correlates of gonococcal infection and of antimicrobial-resistant Neisseria gonorrhoeae among female sex workers, Republic of the Philippines, 1996\u20131997","volume":"179","author":"Klausner JD","year":"1999","unstructured":"Klausner JD, Aplasca MR, Mesola VP, Bolan G, Whittington WL, Holmes KK. 1999. Correlates of gonococcal infection and of antimicrobial-resistant Neisseria gonorrhoeae among female sex workers, Republic of the Philippines, 1996\u20131997. J Infect Dis 179:729\u2013733.","journal-title":"J Infect Dis"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081236"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2011-050466"},{"key":"e_1_3_2_22_2","volume-title":"Response plan to control and manage the threat of multidrug-resistant gonorrhoea in Europe","author":"European Centre for Disease Prevention and Control","year":"2012","unstructured":"European Centre for Disease Prevention and Control. 2012. Response plan to control and manage the threat of multidrug-resistant gonorrhoea in Europe. ECDC, Stockholm, Sweden."},{"key":"e_1_3_2_23_2","volume-title":"Sexually transmitted infections, including HIV, in The Netherlands, 2013","author":"National Institute for Public Health and the Environment","year":"2014","unstructured":"National Institute for Public Health and the Environment. 2014. Sexually transmitted infections, including HIV, in The Netherlands, 2013. Report number 150002005\/2014. National Institute for Public Health and the Environment, Bilthoven, the Netherlands."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12411"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.03932-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.03932-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:53:28Z","timestamp":1645484008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.03932-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1128\/AAC.03932-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.03932-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2014-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}