{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:30:08Z","timestamp":1789810208130,"version":"4.0.1"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Enzymes of the OXA-48 family have become some of the most important beta-lactamases in the world. A new OXA-48 variant (OXA-370) was first described for an<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter hormaechei<\/jats:named-content>strain isolated in Rio Grande do Sul (southern region of Brazil) in 2013. Here we report detection of the<jats:italic>bla<\/jats:italic><jats:sub>OXA-370<\/jats:sub>gene in 24 isolates belonging to three<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae<\/jats:named-content>species (22<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>isolates, 1<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter cloacae<\/jats:named-content>isolate, and 1<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter aerogenes<\/jats:named-content>isolate) collected from five hospitals in Rio de Janeiro, Brazil, in 2013 and 2014. The isolates showed a multidrug resistance profile, and 12.5% were resistant to polymyxin B. Besides<jats:italic>bla<\/jats:italic><jats:sub>OXA-370<\/jats:sub>, no other carbapenemase genes were observed by PCR, whereas<jats:italic>bla<\/jats:italic><jats:sub>OXA-1<\/jats:sub>was found in all isolates and 22 isolates (91.6%) possessed<jats:italic>bla<\/jats:italic><jats:sub>CTX-M-15<\/jats:sub>. Molecular typing of the<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">K. pneumoniae<\/jats:named-content>isolates by pulsed-field gel electrophoresis (PFGE) showed the presence of two clonal groups, i.e., KpA (21 isolates) and KpB (1 isolate). KpA was characterized as sequence type 16 (ST16) and KpB as ST1041 by multilocus sequence typing (MLST). ST16 has been observed for KPC-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">K. pneumoniae<\/jats:named-content>in Rio de Janeiro. Plasmid analysis performed with six representative OXA-370-producing isolates showed plasmids harboring the<jats:italic>bla<\/jats:italic><jats:sub>OXA-370<\/jats:sub>gene in all strains, ranging from 25 kb to 150 kb. This study suggests that there is an urgent need to investigate the presence of OXA-370 and dissemination of the<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">K. pneumoniae<\/jats:named-content>ST16 clone carrying this gene in Brazil.<\/jats:p>","DOI":"10.1128\/aac.04243-14","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T02:31:37Z","timestamp":1432002697000},"page":"4453-4456","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil"],"prefix":"10.1128","volume":"59","author":[{"given":"Polyana Silva","family":"Pereira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Infec\u00e7\u00e3o Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirla","family":"Borghi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Infec\u00e7\u00e3o Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Felipe Machado","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Infec\u00e7\u00e3o Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Augusto Martins","family":"Aires","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Infec\u00e7\u00e3o Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Cleide Ribeiro","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica do Rio de Janeiro Noel Nutels, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marise Dutra","family":"Asensi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Infec\u00e7\u00e3o Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula D'Alincourt","family":"Carvalho-Assef","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Infec\u00e7\u00e3o Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110655"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir202"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks121"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02510-13"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.15-22.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1128\/9781555816728.ch37","volume-title":"Manual of clinical microbiology","author":"Abbott SL","year":"2011","unstructured":"Abbott SL. 2011. Klebsiella, Enterobacter, Citrobacter, Serratia, Plesiomonas, and other Enterobacteriaceae, p 639\u2013657. In Versalovic J, Carroll KC, Jorgensen JG, Funke G, Landry ML, Warnock DW (ed), Manual of clinical microbiology, 10th ed, vol 1. ASM Press, Washington, DC.","edition":"10"},{"key":"e_1_3_2_8_2","volume-title":"CLSI M100-S24","author":"Clinical and Laboratory Standards Institute","year":"2014","unstructured":"Clinical and Laboratory Standards Institute. 2014. Performance standards for antimicrobial susceptibility testing; 21st informational supplement. CLSI M100-S24. 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