{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:11:02Z","timestamp":1789852262061,"version":"4.0.1"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Presently, the arsenal of antimalarial drugs is limited and needs to be replenished. We evaluated the potential antimalarial activity of two water-soluble derivatives of nocathiacin (BMS461996 and BMS411886) against the asexual blood stages of\n Plasmodium falciparum<\/jats:named-content>\n . Nocathiacins are a thiazolyl peptide group of antibiotics, are structurally related to thiostrepton, have potent activity against a wide spectrum of multidrug-resistant Gram-positive bacteria, and inhibit protein synthesis. The\n in vitro<\/jats:italic>\n growth inhibition assay was done using three laboratory strains of\n P. falciparum<\/jats:named-content>\n displaying various levels of chloroquine (CQ) susceptibility. Our results indicate that BMS461996 has potent antimalarial activity and inhibits parasite growth with mean 50% inhibitory concentrations (IC\n 50<\/jats:sub>\n s) of 51.55 nM for\n P. falciparum<\/jats:named-content>\n 3D7 (CQ susceptible), 85.67 nM for\n P. falciparum<\/jats:named-content>\n Dd2 (accelerated resistance to multiple drugs [ARMD]), and 99.44 nM for\n P. falciparum<\/jats:named-content>\n K1 (resistant to CQ, pyrimethamine, and sulfadoxine). Similar results at approximately 7-fold higher IC\n 50<\/jats:sub>\n s were obtained with BMS411886 than with BMS461996. We also tested the effect of BMS491996 on gametocytes; our results show that at a 20-fold excess of the mean IC\n 50<\/jats:sub>\n , gametocytes were deformed with a pyknotic nucleus and growth of stage I to IV gametocytes was arrested. This preliminary study shows a significant potential for nocathiacin analogues to be developed as antimalarial drug candidates and to warrant further investigation.\n <\/jats:p>","DOI":"10.1128\/aac.04294-14","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T02:56:01Z","timestamp":1426560961000},"page":"3174-3179","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["In Vitro<\/i>\n Antimalarial Activity of Novel Semisynthetic Nocathiacin I Antibiotics"],"prefix":"10.1128","volume":"59","author":[{"given":"Indu","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Hampton University, Hampton, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"McCutchan","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.30875\/9f925144-en"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208394"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-396"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2011.12.001"},{"key":"e_1_3_2_6_2","volume-title":"Molecular approaches to malaria","author":"Sharma I","year":"2005","unstructured":"Sharma I, McCutchan TF. 2005. Chapter 18. Plasmodium ribosome and opportunities for drug intervention. In Sherman IW (ed.), Molecular approaches to malaria. ASM Press, Washington, DC."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.01.005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.105163.110"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.56.226"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038320"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00218-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.5.1067"},{"key":"e_1_3_2_13_2","first-page":"2046","article-title":"Inhibition of Plasmodium falciparum protein synthesis","volume":"272","author":"McConkey GA","year":"1997","unstructured":"McConkey GA, Rogers MJ, McCutchan TF. 1997. Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton. J Biol Chem 272:2046\u20132049.","journal-title":"Targeting the plastid-like organelle with thiostrepton. J Biol Chem"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00226-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01096-10"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3697-3701.2004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/273621a0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/3280287"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1803-1806.2004"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(87)90147-5"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004551"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-335"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-268"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.08.058"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652410791065273"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.715"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.04294-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.04294-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:06:19Z","timestamp":1645484779000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.04294-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1128\/AAC.04294-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.04294-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"2014-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}