{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:22:44Z","timestamp":1790896964217,"version":"4.1.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion of\n            <jats:italic>clpX<\/jats:italic>\n            significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX is the chaperone component of the ClpXP two-component proteolytic system. Nevertheless, no changes in resistance were observed in a\n            <jats:italic>clpP<\/jats:italic>\n            knockout strain expressing\n            <jats:italic>msr<\/jats:italic>\n            (A), demonstrating that ClpX affects Msr(A) independently of ClpP.\n          <\/jats:p>","DOI":"10.1128\/aac.04367-14","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T02:32:47Z","timestamp":1427164367000},"page":"3611-3614","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["ClpP-Independent Function of ClpX Interferes with Telithromycin Resistance Conferred by Msr(A) in Staphylococcus aureus"],"prefix":"10.1128","volume":"59","author":[{"given":"Vladimir","family":"Vimberg","sequence":"first","affiliation":[{"name":"Institute of Microbiology, The Czech Academy of Sciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Lenart","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, The Czech Academy of Sciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Janata","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, The Czech Academy of Sciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-4763","authenticated-orcid":false,"given":"Gabriela","family":"Balikova Novotna","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, The Czech Academy of Sciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr453"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-453"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01749.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02932188"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki378"},{"key":"e_1_3_3_7_2","volume-title":"Resistance of bacteria to antibiotics","author":"Urbaskova P","year":"1998","unstructured":"Urbaskova P. 1998. 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