{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:09:23Z","timestamp":1773691763321,"version":"3.50.1"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Clinical breakpoints (CBPs) have not been established for the\n Mucorales<\/jats:named-content>\n and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four\n Mucorales<\/jats:named-content>\n species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10\n Apophysomyces variabilis<\/jats:named-content>\n , 32\n Cunninghamella bertholletiae<\/jats:named-content>\n , 136\n Lichtheimia corymbifera<\/jats:named-content>\n , 10\n Mucor indicus<\/jats:named-content>\n , 123\n M. circinelloides<\/jats:named-content>\n , 19\n M. ramosissimus<\/jats:named-content>\n , 349\n Rhizopus arrhizus<\/jats:named-content>\n , 146\n R. microsporus<\/jats:named-content>\n , 33\n Rhizomucor pusillus<\/jats:named-content>\n , and 36\n Syncephalastrum racemosum<\/jats:named-content>\n isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising \u226595% and \u226597.5% of the modeled populations were as follows: amphotericin B ECVs for\n L. corymbifera<\/jats:named-content>\n were 1 and 2 \u03bcg\/ml, those for\n M. circinelloides<\/jats:named-content>\n were 1 and 2 \u03bcg\/ml, those for\n R. arrhizus<\/jats:named-content>\n were 2 and 4 \u03bcg\/ml, and those for\n R. microsporus<\/jats:named-content>\n were 2 and 2 \u03bcg\/ml, respectively; posaconazole ECVs for\n L. corymbifera<\/jats:named-content>\n were 1 and 2, those for\n M. circinelloides<\/jats:named-content>\n were 4 and 4, those for\n R. arrhizus<\/jats:named-content>\n were 1 and 2, and those for\n R. microsporus<\/jats:named-content>\n were 1 and 2, respectively; both itraconazole ECVs for\n R. arrhizus<\/jats:named-content>\n were 2 \u03bcg\/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.\n <\/jats:p>","DOI":"10.1128\/aac.04435-14","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T18:35:13Z","timestamp":1423679713000},"page":"1745-1750","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":122,"title":["Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of Mucorales"],"prefix":"10.1128","volume":"59","author":[{"given":"A.","family":"Espinel-Ingroff","sequence":"first","affiliation":[{"name":"VCU Medical Center, Richmond, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cordoba","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas Dr. C. 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Malbr\u00e1n, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dannaoui","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Descartes, Facult\u00e9 de M\u00e9decine, APHP, H\u00f4pital Europ\u00e9en Georges Pompidou, Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Dufresne","sequence":"additional","affiliation":[{"name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec, Laboratoire de Sant\u00e9 Publique du Qu\u00e9bec, Sainte-Anne-de-Bellevue, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fothergill","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Guarro","sequence":"additional","affiliation":[{"name":"Facultat de Medicina, IISPV, URV, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kidd","sequence":"additional","affiliation":[{"name":"National Mycology Reference Centre, SA Pathology, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"The Innsbruck Medical University, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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