{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:05:37Z","timestamp":1762542337381},"reference-count":18,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Widespread resistance to most antimalaria drugs in use has prompted the search for novel candidate compounds with activity against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium<\/jats:named-content>\n            asexual blood stages to be developed for treatment. In addition, the current malaria eradication programs require the development of drugs that are effective against all stages of the parasite life cycle. We have analyzed the antimalarial properties of xenomycins, a novel subclass of small molecule compounds initially isolated for anticancer activity and similarity to quinacrine in biological effects on mammalian cells.\n            <jats:italic>In vitro<\/jats:italic>\n            studies show potent activity of Xenomycins against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            . Oral administration of xenomycins in mouse models result in effective clearance of liver and blood asexual and sexual stages, as well as effective inhibition of transmission to mosquitoes. These characteristics position xenomycins as antimalarial candidates with potential activity in prevention, treatment and elimination of this disease.\n          <\/jats:p>","DOI":"10.1128\/aac.04704-14","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T03:19:23Z","timestamp":1418699963000},"page":"1427-1434","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Small-Molecule Xenomycins Inhibit All Stages of the Plasmodium Life Cycle"],"prefix":"10.1128","volume":"59","author":[{"given":"Jessey","family":"Erath","sequence":"first","affiliation":[{"name":"New York University School of Medicine, Department of Microbiology, Division of Parasitology, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Gallego-Delgado","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, Department of Microbiology, Division of Parasitology, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyue","family":"Xu","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, Department of Microbiology, Division of Parasitology, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grasiella","family":"Andriani","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, Department of Microbiology, Division of Parasitology, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Tanghe","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, Department of Microbiology, Division of Parasitology, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina V.","family":"Gurova","sequence":"additional","affiliation":[{"name":"Roswell Park Cancer Institute, Department of Cell Stress Biology, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Gudkov","sequence":"additional","affiliation":[{"name":"Roswell Park Cancer Institute, Department of Cell Stress Biology, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Purmal","sequence":"additional","affiliation":[{"name":"Incuron LLC, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rydkina","sequence":"additional","affiliation":[{"name":"Roswell Park Cancer Institute, Department of Cell Stress Biology, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, Department of Microbiology, Division of Parasitology, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"World malaria report","author":"World Health Organization","year":"2013","unstructured":"World Health Organization. 2013. 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