{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:09:01Z","timestamp":1793758141421,"version":"4.6.1"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Eravacycline demonstrated\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC\n                    <jats:sub>50<\/jats:sub>\n                    \/MIC\n                    <jats:sub>90<\/jats:sub>\n                    values, respectively, for\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n                    of 0.12\/0.5 \u03bcg\/ml,\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>\n                    of 0.25\/1 \u03bcg\/ml,\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter aerogenes<\/jats:named-content>\n                    of 0.25\/1 \u03bcg\/ml,\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter cloacae<\/jats:named-content>\n                    0.5\/1 \u03bcg\/ml, and\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:named-content>\n                    of 0.5\/1 \u03bcg\/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n                    , eravacycline MICs correlated with increased expression of the\n                    <jats:italic>adeB<\/jats:italic>\n                    gene.\n                  <\/jats:p>","DOI":"10.1128\/aac.04809-14","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T22:11:33Z","timestamp":1419286293000},"page":"1802-1805","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":139,"title":["Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii, Including Multidrug-Resistant Isolates, from New York City"],"prefix":"10.1128","volume":"59","author":[{"given":"Marie","family":"Abdallah","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olawole","family":"Olafisoye","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Cortes","sequence":"additional","affiliation":[{"name":"The Dr. James J. Rahal Jr. Division of Infectious Diseases, New York Hospital Queens, Flushing, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Urban","sequence":"additional","affiliation":[{"name":"The Dr. James J. Rahal Jr. Division of Infectious Diseases, New York Hospital Queens, Flushing, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Landman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Quale","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm129"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks063"},{"key":"e_1_3_2_4_2","first-page":"165","article-title":"Vital signs: carbapenem-resistant Enterobacteriaceae","volume":"62","author":"Centers for Disease Control and Prevention","year":"2013","unstructured":"Centers for Disease Control and Prevention. 2013. Vital signs: carbapenem-resistant Enterobacteriaceae. MMWR Morb Mortal Wkly Rev 62:165\u2013170.","journal-title":"MMWR Morb Mortal Wkly Rev"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03667.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-08"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/652237"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01288-13"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06187-11"},{"key":"e_1_3_2_10_2","volume-title":"Twenty-second informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2012","unstructured":"Clinical and Laboratory Standards Institute. 2012. Performance standards for antimicrobial susceptibility testing. Approved standard M100-S22. Twenty-second informational supplement. 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