{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:26:52Z","timestamp":1793824012900,"version":"4.6.1"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Malaria in the China-Myanmar border region is still severe; local transmission of both falciparum and vivax malaria persists, and there is a risk of geographically expanding antimalarial resistance. In this research, the\n            <jats:italic>pfmdr1<\/jats:italic>\n            ,\n            <jats:italic>pfcrt<\/jats:italic>\n            ,\n            <jats:italic>pvmdr1<\/jats:italic>\n            , and K13-propeller genotypes were determined in 26\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            and 64\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium vivax<\/jats:named-content>\n            isolates from Yingjiang county of Yunnan province. The\n            <jats:italic>pfmdr1<\/jats:italic>\n            (11.5%),\n            <jats:italic>pfcrt<\/jats:italic>\n            (34.6%), and\n            <jats:italic>pvmdr1<\/jats:italic>\n            (3.1%) mutations were prevalent at the China-Myanmar border. The indigenous samples exhibited prevalences of 14.3%, 28.6%, and 14.3% for\n            <jats:italic>pfmdr1<\/jats:italic>\n            N86Y,\n            <jats:italic>pfcrt<\/jats:italic>\n            K76T, and\n            <jats:italic>pfcrt<\/jats:italic>\n            M74I, respectively, whereas the samples from Myanmar showed prevalences of 10.5%, 21.1%, and 5.3%, respectively. The most prevalent genotypes of\n            <jats:italic>pfmdr1<\/jats:italic>\n            and\n            <jats:italic>pfcrt<\/jats:italic>\n            were Y\n            <jats:sub>86<\/jats:sub>\n            Y\n            <jats:sub>184<\/jats:sub>\n            and M\n            <jats:sub>74<\/jats:sub>\n            N\n            <jats:sub>75<\/jats:sub>\n            T\n            <jats:sub>76<\/jats:sub>\n            , respectively. No\n            <jats:italic>pvmdr1<\/jats:italic>\n            mutation occurred in the indigenous samples but was observed in two cases coming from Myanmar. In addition, we are the first to report on 10 patients (38.5%) with five different K13 point mutations. The F446I allele is predominant (19.2%), and its prevalence was 28.6% in the indigenous samples of Yingjiang county and 15.8% in samples from Myanmar. The present data might be helpful for enrichment of the molecular surveillance of antimalarial resistance and useful for developing and updating guidance for the use of antimalarials in this region.\n          <\/jats:p>","DOI":"10.1128\/aac.04843-14","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T03:01:46Z","timestamp":1424228506000},"page":"2554-2559","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Amplification of\n            <i>pfmdr1<\/i>\n            ,\n            <i>pfcrt<\/i>\n            ,\n            <i>pvmdr1<\/i>\n            , and K13 Propeller Polymorphisms Associated with Plasmodium falciparum and Plasmodium vivax Isolates from the China-Myanmar Border"],"prefix":"10.1128","volume":"59","author":[{"given":"Jun","family":"Feng","sequence":"first","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, MOH and WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daili","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yingjiang County Center for Disease Control and Prevention, Yunnan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Lin","sequence":"additional","affiliation":[{"name":"Yingjiang County Center for Disease Control and Prevention, Yunnan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, MOH and WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yan","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, MOH and WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigui","family":"Xia","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, MOH and WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"674","article-title":"Malaria trends and challenges in the Greater Mekong Subregion","volume":"40","author":"Delacollette C","year":"2009","unstructured":"Delacollette C, D'Souza C, Christophel E, Thimasarn K, Abdur R, Bell D, Dai TC, Gopinath D, Lu S, Mendoza R, Ortega L, Rastogi R, Tantinimitkul C, Ehrenberg J. 2009. 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