{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:57:09Z","timestamp":1790009829747,"version":"4.0.1"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            ASP9726 is an investigational echinocandin with\n            <jats:italic>in vitro<\/jats:italic>\n            activity against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus<\/jats:named-content>\n            species. We evaluated the pharmacokinetics and efficacy of this agent in an established guinea pig model of invasive pulmonary aspergillosis. ASP9726 plasma concentrations were measured in guinea pigs administered either a single dose or multiple doses of this agent at 2.5, 5, and 10 mg\/kg of body weight\/day by subcutaneous injection. Immunosuppressed guinea pigs were inoculated with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. fumigatus<\/jats:named-content>\n            AF293, and ASP9726 (2.5, 5, and 10 mg\/kg\/day), voriconazole (10 mg\/kg by oral gavage twice daily), or caspofungin (3 mg\/kg\/day by intraperitoneal injection) was administered for 8 days. Changes in fungal burden were measured by enumerating CFU and by quantitative PCR of specimens from within the lungs, as well as by analysis of serum (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan and galactomannan. Lung histopathology was also evaluated. ASP9726 plasma concentrations increased in a dose-proportional manner, and the drug was well tolerated at each dose. Each dose of ASP9726, voriconazole, and caspofungin significantly reduced pulmonary fungal burden as measured by quantitative PCR and by determining (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan and galactomannan levels, but only voriconazole significantly reduced numbers of CFU. ASP9726 at 5 mg\/kg also significantly improved survival. Histopathology demonstrated morphological changes in hyphae in animals exposed to ASP9726 and caspofungin, consistent with the activities of the echinocandins. These results suggest that ASP9726 may be efficacious for the treatment of invasive pulmonary aspergillosis.\n          <\/jats:p>","DOI":"10.1128\/aac.04857-14","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T02:03:07Z","timestamp":1425952987000},"page":"2875-2881","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of the Investigational Echinocandin ASP9726 in a Guinea Pig Model of Invasive Pulmonary Aspergillosis"],"prefix":"10.1128","volume":"59","author":[{"given":"Nathan P.","family":"Wiederhold","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Astellas Pharmaceuticals, Inc., Tsubuka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie A.","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica L.","family":"Herrera","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Wickes","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Patterson","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/318483"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-093OC"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3488"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2471"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.9.3001-3012.2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.12.8.1313"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/423380"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/423381"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.03.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.12.116"},{"key":"e_1_3_2_12_2","volume-title":"Antifungal activity, plasma pharmacokinetics and safety of second-generation echinocandin ASP9726 in experimental pulmonary aspergillosis in persistently neutropenic rabbits, abstr M-981. 52nd Intersci Conf Antimicrob Agents Chemother","author":"Petraitis V","year":"2012","unstructured":"Petraitis V, Petraitiene R, Such KA, Moradi PW, Strauss GE, Petraityte E, Fleener S, Akamatsu S, Matsumoto S, Walsh TJ. 2012. Antifungal activity, plasma pharmacokinetics and safety of second-generation echinocandin ASP9726 in experimental pulmonary aspergillosis in persistently neutropenic rabbits, abstr M-981. 52nd Intersci Conf Antimicrob Agents Chemother, San Francisco, CA."},{"key":"e_1_3_2_13_2","volume-title":"Evaluation of ASP9726 on glucan synthase inhibition from echinocandin susceptible and resistant fungi (abstr F-822). 52nd Intersci Conf Antimicrob Agents Chemother","author":"Paderu P","year":"2012","unstructured":"Paderu P, Jimenez-Ortigosa C, Akamatsu S, Matsumoto S, Perlin D. 2012. Evaluation of ASP9726 on glucan synthase inhibition from echinocandin susceptible and resistant fungi (abstr F-822). 52nd Intersci Conf Antimicrob Agents Chemother, San Francisco, CA."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00787-06"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1908-1911.2004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01425-07"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02142-12"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04332"},{"key":"e_1_3_2_19_2","volume-title":"Document M38-A2","author":"CLSI","year":"2008","unstructured":"CLSI. 2008. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard, 2nd ed. Document M38-A2. 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