{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:53:28Z","timestamp":1783612408116,"version":"3.55.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Thirty-nine\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>\n            carbapenemase (KPC)-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Pseudomonas aeruginosa<\/jats:named-content>\n            isolates, all exhibiting high-level resistance to carbapenems and other \u03b2-lactam antibiotics, were isolated in Hangzhou, China. Molecular epidemiology analysis indicated the presence of two dominant clones, namely, clones A and B, both of which belong to sequence type 463 (ST463). A genetic environment analysis demonstrated that both clones harbor an IS\n            <jats:italic>Kpn8<\/jats:italic>\n            transposase,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>KPC-2<\/jats:sub>\n            , and an IS\n            <jats:italic>Kpn6<\/jats:italic>\n            -like transposase. These findings depict the features of clonal expansion and transmission of KPC-2-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. aeruginosa<\/jats:named-content>\n            strains in Hangzhou, China.\n          <\/jats:p>","DOI":"10.1128\/aac.04903-14","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T03:01:46Z","timestamp":1424228506000},"page":"2914-2917","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Emergence of KPC-2-Producing Pseudomonas aeruginosa Sequence Type 463 Isolates in Hangzhou, China"],"prefix":"10.1128","volume":"59","author":[{"given":"Yan-yan","family":"Hu","sequence":"first","affiliation":[{"name":"2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-xia","family":"Gu","sequence":"additional","affiliation":[{"name":"2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-chang","family":"Cai","sequence":"additional","affiliation":[{"name":"2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"e_1_3_2_3_2","first-page":"321","article-title":"CHINET 2012 surveillance of bacterial resistance in China","volume":"13","author":"Wang F","year":"2013","unstructured":"Wang F, Zhu DM, Hu FP, Jiang XF, Hu ZD, Li Q, Sun ZY, Chen ZJ, Xu YC, Zhang XJ, Wang CQ, Wang AM, Ni YX, Sun JY, Zhu YZ, Yu YS, Lin J, Xu YH, Shen JL, Su DH, Zhuo C, Wei LH, Wu L, Zhang ZX, Ji P, Zhang H, Kong J, Hu YJ, Ai XM, Shan B, Du Y. 2013. CHINET 2012 surveillance of bacterial resistance in China. Chin J Infect Chemother 13:321\u2013330.","journal-title":"Chin J Infect Chemother"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr290"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70168-3"},{"key":"e_1_3_2_6_2","volume-title":"CLSI document M100-S24","author":"CLSI","year":"2014","unstructured":"CLSI. 2014. Performance standards for antimicrobial susceptibility testing; 24th informational supplement. CLSI document M100-S24. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1151-1161.2001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-2024-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2224-2228.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01539-07"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00260-09"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00912-13"},{"key":"e_1_3_2_13_2","volume-title":"CLSI document M100-S15","author":"Clinical and Laboratory Standards Institute","year":"2005","unstructured":"Clinical and Laboratory Standards Institute. 2005. Performance standards for antimicrobial susceptibility testing: 15th informational supplement. CLSI document M100-S15. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05519-11"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5483-5490.2005"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.04903-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.04903-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:00:26Z","timestamp":1645484426000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.04903-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1128\/AAC.04903-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.04903-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"2014-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}