{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:57:48Z","timestamp":1775008668945,"version":"3.50.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Pantothenamides inhibit blood-stage\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            with potencies (50% inhibitory concentration [IC\n            <jats:sub>50<\/jats:sub>\n            ], \u223c20 nM) similar to that of chloroquine. They target processes dependent on pantothenate, a precursor of the essential metabolic cofactor coenzyme A. However, their antiplasmodial activity is reduced due to degradation by serum pantetheinase. Minor modification of the pantothenamide structure led to the identification of \u03b1-methyl-\n            <jats:italic>N<\/jats:italic>\n            -phenethyl-pantothenamide, a pantothenamide resistant to degradation, with excellent antiplasmodial activity (IC\n            <jats:sub>50<\/jats:sub>\n            , 52 \u00b1 6 nM), target specificity, and low toxicity.\n          <\/jats:p>","DOI":"10.1128\/aac.04970-14","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T01:42:34Z","timestamp":1428370954000},"page":"3666-3668","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity"],"prefix":"10.1128","volume":"59","author":[{"given":"Cristiano J.","family":"Macuamule","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick T.","family":"Tjhin","sequence":"additional","affiliation":[{"name":"Research School of Biology, College of Medicine, Biology, and Environment, The Australian National University, Canberra, ACT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collins E.","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Barnard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizb\u00e9","family":"Koekemoer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"de Villiers","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Saliba","sequence":"additional","affiliation":[{"name":"Research School of Biology, College of Medicine, Biology, and Environment, The Australian National University, Canberra, ACT, Australia"},{"name":"Medical School, College of Medicine, Biology, and Environment, The Australian National University, Canberra, ACT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-8226","authenticated-orcid":false,"given":"Erick","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.30875\/9f925144-en"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2624"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207564"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140240"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152610791163390"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/B978-008045382-8.00141-6","volume-title":"Comprehensive natural products II: chemistry and biology","author":"Strauss E","year":"2010","unstructured":"Strauss E. 2010. 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