{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:54:18Z","timestamp":1791248058248,"version":"4.1.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene has been reported to be often located on broad-host-range plasmids of the IncA\/C type in clinical but also environmental bacteria recovered from the New Delhi, India, area. IncA\/C-type plasmids are the main vehicles for the spread of the cephalosporinase gene\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CMY-2<\/jats:sub>\n            , frequently identified in the United States, Canada, and Europe. In this study, we completed the sequence of IncA\/C plasmid pNDM-KN carrying the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene, recovered from a\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>\n            isolate from Kenya. This sequence was compared with those of three IncA\/C-type reference plasmids from\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            ,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Yersinia ruckeri<\/jats:named-content>\n            , and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Photobacterium damselae<\/jats:named-content>\n            . Comparative analysis showed that the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene was located on a widely diffused plasmid scaffold known to be responsible for the spread of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CMY-2<\/jats:sub>\n            -like genes and consequently for resistance to broad-spectrum cephalosporins. Considering that IncA\/C plasmids possess a broad host range, this scaffold might support a large-scale diffusion of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene among Gram-negative rods.\n          <\/jats:p>","DOI":"10.1128\/aac.05116-11","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T02:31:59Z","timestamp":1322620319000},"page":"783-786","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":145,"title":["Evolution of IncA\/C\n            <i>bla<\/i>\n            <sub>CMY-2<\/sub>\n            -Carrying Plasmids by Acquisition of the\n            <i>bla<\/i>\n            <sub>NDM-1<\/sub>\n            Carbapenemase Gene"],"prefix":"10.1128","volume":"56","author":[{"given":"Alessandra","family":"Carattoli","sequence":"first","affiliation":[{"name":"Department of Infectious, Parasitic, and Immuno-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic, and Immuno-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Facult\u00e9 de M\u00e9decine et Universit\u00e9 Paris-Sud, K.-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my A.","family":"Bonnin","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Facult\u00e9 de M\u00e9decine et Universit\u00e9 Paris-Sud, K.-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Facult\u00e9 de M\u00e9decine et Universit\u00e9 Paris-Sud, K.-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.08.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijantimicag.2007.07.031","article-title":"Characterisation of plasmids encoding extended-spectrum beta-lactamase and CMY-2 in Escherichia coli isolated from animal farms","volume":"31","author":"Blanc V","year":"2008","unstructured":"BlancV. 2008. Characterisation of plasmids encoding extended-spectrum beta-lactamase and CMY-2 in Escherichia coli isolated from animal farms. Int. J. Antimicrob. Agents 31: 76\u201378.","journal-title":"Int. J. Antimicrob. Agents"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/mdr.2011.0037","article-title":"Transposon Tn5393e carrying the aphA1-containing transposon Tn6023 upstream of strAB does not confer resistance to streptomycin","volume":"17","author":"Cain AK","year":"2011","unstructured":"CainAK HallR. 2011. Transposon Tn5393e carrying the aphA1-containing transposon Tn6023 upstream of strAB does not confer resistance to streptomycin. Microb. Drug Resist. 17: 389\u2013394.","journal-title":"Microb. 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Comparison of CMY-2 plasmids isolated from human, animal, and environmental Escherichia coli and Salmonella spp. from Canada. Diagn. Microbiol. Infect. Dis. 67: 387\u2013391.","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq520"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/mdr.2006.12.269","article-title":"Antimicrobial resistance in nontyphoidal Salmonella from food sources in Colombia: evidence for an unusual plasmid-localized class 1 integron in serotypes Typhimurium and Anatum","volume":"12","author":"O'Mahoni R","year":"2006","unstructured":"O'MahoniR. 2006. Antimicrobial resistance in nontyphoidal Salmonella from food sources in Colombia: evidence for an unusual plasmid-localized class 1 integron in serotypes Typhimurium and Anatum. Microb. Drug Resist. 12: 269\u2013277.","journal-title":"Microb. 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