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FTU-1 hydrolyzes penicillin antibiotics with catalytic efficiencies of 10<jats:sup>5<\/jats:sup>to 10<jats:sup>6<\/jats:sup>M<jats:sup>\u22121<\/jats:sup>s<jats:sup>\u22121<\/jats:sup>and cephalosporins and carbapenems with catalytic efficiencies of 10<jats:sup>2<\/jats:sup>to 10<jats:sup>3<\/jats:sup>M<jats:sup>\u22121<\/jats:sup>s<jats:sup>\u22121<\/jats:sup>, but the monobactam aztreonam and the cephamycin cefoxitin are not substrates for the enzyme. FTU-1 shares 21 to 34% amino acid sequence identity with other class A \u03b2-lactamases and harbors two cysteine residues conserved in all class A carbapenemases. FTU-1 is the first weak class A carbapenemase that is native to<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Francisella tularensis<\/jats:named-content>.<\/jats:p>","DOI":"10.1128\/aac.05305-11","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T19:06:06Z","timestamp":1321383966000},"page":"666-671","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["The Class A \u03b2-Lactamase FTU-1 Is Native to Francisella tularensis"],"prefix":"10.1128","volume":"56","author":[{"given":"Nuno T.","family":"Antunes","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Frase","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Toth","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei B.","family":"Vakulenko","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007041"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000947"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00203-006-0140-6","article-title":"The Bla2 beta-lactamase from the live-vaccine strain of Francisella tularensis encodes a functional protein that is only active against penicillin-class beta-lactam antibiotics","volume":"186","author":"Bina XR","year":"2006","unstructured":"BinaXR WangC MillerMA BinaJE. 2006. 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